Rinl MGI Mouse Gene Detail - MGI:2444024 - Ras and Rab interactor-like

Symbol

Rinl
Name

Ras and Rab interactor-like
Synonyms

5830482F20Rik, 9930116N10Rik

Feature Type

protein coding gene
IDs

MGI:2444024
NCBI Gene: 320435
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:28488394-28498388 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.93 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

352 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444024	protein coding gene	Chr7:28488186-28498390 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031961	protein coding gene	Chr7:27630060-27642311 (+)
A/J	MGP_AJ_G0031939	protein coding gene	Chr7:26937525-26947383 (+)
AKR/J	MGP_AKRJ_G0031871	protein coding gene	Chr7:27628600-27641661 (+)
BALB/cJ	MGP_BALBcJ_G0031946	protein coding gene	Chr7:27096297-27106429 (+)
C3H/HeJ	MGP_C3HHeJ_G0031665	protein coding gene	Chr7:28004258-28015943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032410	protein coding gene	Chr7:28529695-28545110 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029462	protein coding gene	Chr7:27999957-28009352 (+)
CAST/EiJ	MGP_CASTEiJ_G0031000	protein coding gene	Chr7:21325684-21337226 (+)
CBA/J	MGP_CBAJ_G0031631	protein coding gene	Chr7:29796570-29814687 (+)
DBA/2J	MGP_DBA2J_G0031783	protein coding gene	Chr7:26688673-26699092 (+)
FVB/NJ	MGP_FVBNJ_G0031740	protein coding gene	Chr7:26767138-26782764 (+)
LP/J	MGP_LPJ_G0031863	protein coding gene	Chr7:27949294-27964410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031776	protein coding gene	Chr7:29268296-29288453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032440	protein coding gene	Chr7:27107100-27121052 (+)
PWK/PhJ	MGP_PWKPhJ_G0030725	protein coding gene	Chr7:21714164-21724557 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030558	protein coding gene	Chr7:18129208-18145280 (+)
WSB/EiJ	MGP_WSBEiJ_G0031109	protein coding gene	Chr7:27480109-27491165 (+)

Human Ortholog

RINL, Ras and Rab interactor like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RINL, Ras and Rab interactor like
Links

HGNC:24795

NCBI Gene ID: 126432

neXtProt AC: NX_Q6ZS11

UniProt: Q6ZS11
Chr Location

19q13.2; chr19:38867830-38878275 (-) GRCh38

MGI Vertebrate Homology

Rinl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RINL
Gene Tree

Rinl

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

11
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increases in T follicular helper cell numbers with age and following infection.

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

52

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

52
RefSeq

8
UniProt

2
CCDS

CCDS21056.1

Ensembl

ENSMUSG00000051735 (Evidence)
NCBI Gene

320435

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051735	Ensembl Gene Model \| MGI Sequence Detail	9995	C57BL/6J	± kb
transcript	ENSMUST00000059857	Ensembl \| MGI Sequence Detail	2871	Not Applicable
polypeptide	ENSMUSP00000058447	Ensembl \| MGI Sequence Detail	563	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014017 Ras and Rab interactor-like protein

(term hierarchy)
InterPro Domains

IPR036860 SH2 domain superfamily

IPR045046 Vacuolar protein sorting-associated protein 9-like

IPR003123 VPS9 domain

IPR037191 VPS9 domain superfamily

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All nucleic 54

cDNA 54

Microarray probesets 6

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MGI:1925333

Summaries

All 32

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rinl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65517	Chr7:28487198-28487211 (+)	-1,189 bp
Tssr65518	Chr7:28487393-28487442 (+)	-976 bp
Tssr65519	Chr7:28487648-28487664 (+)	-738 bp
Tssr65520	Chr7:28487677-28487691 (+)	-710 bp
Tssr65521	Chr7:28488364-28488367 (+)	-28 bp
Tssr65522	Chr7:28488380-28488411 (+)	2 bp
Tssr65523	Chr7:28495397-28495426 (+)	7,018 bp
Tssr65524	Chr7:28495434-28495495 (+)	7,071 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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