Nlrp10 MGI Mouse Gene Detail - MGI:2444084 - NLR family, pyrin domain containing 10

Symbol

Nlrp10
Name

NLR family, pyrin domain containing 10
Synonyms

6430548I20Rik, Nalp10, Pynod

Feature Type

protein coding gene
IDs

MGI:2444084
NCBI Gene: 244202
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:108521060-108529365 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.21 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

259 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444084	protein coding gene	Chr7:108521059-108529385 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032835	protein coding gene	Chr7:112319288-112330377 (-)
A/J	MGP_AJ_G0032819	protein coding gene	Chr7:109544326-109569701 (-)
AKR/J	MGP_AKRJ_G0032750	protein coding gene	Chr7:112285981-112301197 (-)
BALB/cJ	MGP_BALBcJ_G0032823	protein coding gene	Chr7:109255942-109264235 (-)
C3H/HeJ	MGP_C3HHeJ_G0032533	protein coding gene	Chr7:112331324-112338676 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033329	protein coding gene	Chr7:117009823-117020046 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030302	protein coding gene	Chr7:111151075-111157998 (-)
CAST/EiJ	MGP_CASTEiJ_G0031861	protein coding gene	Chr7:103853350-103861565 (-)
CBA/J	MGP_CBAJ_G0032506	protein coding gene	Chr7:120833347-120844702 (-)
DBA/2J	MGP_DBA2J_G0032658	protein coding gene	Chr7:107666479-107676707 (-)
FVB/NJ	MGP_FVBNJ_G0032611	protein coding gene	Chr7:107515480-107523848 (-)
LP/J	MGP_LPJ_G0032752	protein coding gene	Chr7:113883629-113891946 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032643	protein coding gene	Chr7:122514915-122522188 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033350	protein coding gene	Chr7:111314002-111323460 (-)
PWK/PhJ	MGP_PWKPhJ_G0031568	protein coding gene	Chr7:100468545-100477170 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031416	protein coding gene	Chr7:98001573-98009765 (-)
WSB/EiJ	MGP_WSBEiJ_G0031974	protein coding gene	Chr7:112148191-112157832 (-)

Human Ortholog

NLRP10, NLR family pyrin domain containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NLRP10, NLR family pyrin domain containing 10
Synonyms

CLR11.1, NALP10, NOD8, PAN5, PYNOD
Links

HGNC:21464

NCBI Gene ID: 338322

neXtProt AC: NX_Q86W26

UniProt: Q86W26
Chr Location

11p15.4; chr11:7957537-7965447 (-) GRCh38

MGI Vertebrate Homology

Nlrp10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NLRP10
Gene Tree

Nlrp10

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Nlrp10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available

Mice homozygous for a knock-out allele display a global defect in adaptive immune responses with impaired dendritic cell migration to lymph nodes.

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

2
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

4
CCDS

CCDS21730.1

Ensembl

ENSMUSG00000049709 (Evidence)
NCBI Gene

244202

			Length	Strain/Species	Flank
genomic	244202	NCBI Gene Model \| MGI Sequence Detail	8306	C57BL/6J	± kb
transcript	NM_175532	RefSeq \| MGI Sequence Detail	4483	C57BL/6
polypeptide	Q8CCN1	UniProt \| EBI \| MGI Sequence Detail	673	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011265 NACHT, LRR and PYD domains-containing protein 10

(term hierarchy)
PDB

2DO9
InterPro Domains

IPR004020 DAPIN domain

IPR011029 Death-like domain superfamily

IPR007111 NACHT nucleoside triphosphatase

IPR050637 NLRP family, innate immunity and inflammation regulators

IPR041075 NOD2, winged helix domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 21
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:354090 Zheng D, et al., Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation. Nat Immunol. 2023 Apr;24(4):585-594

TSS for Nlrp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74169	Chr7:108529375-108529390 (-)	-18 bp
Tssr74168	Chr7:108529358-108529371 (-)	0 bp
Tssr74167	Chr7:108523598-108523602 (-)	5,765 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24