Acsm5 MGI Mouse Gene Detail - MGI:2444086 - acyl-CoA synthetase medium-chain family member 5

Symbol

Acsm5
Name

acyl-CoA synthetase medium-chain family member 5
Synonyms

C730027J19Rik

Feature Type

protein coding gene
IDs

MGI:2444086
NCBI Gene: 272428
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:119125354-119142583 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 63.94 cM
Mapping Data

1 experiment

SNPs within 2kb

601 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444086	protein coding gene	Chr7:119118686-119144774 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032912	protein coding gene	Chr7:123425112-123445433 (+)
A/J	MGP_AJ_G0032895	protein coding gene	Chr7:120250499-120268340 (+)
AKR/J	MGP_AKRJ_G0032827	protein coding gene	Chr7:123352152-123371071 (+)
BALB/cJ	MGP_BALBcJ_G0032900	protein coding gene	Chr7:119978565-119995913 (+)
C3H/HeJ	MGP_C3HHeJ_G0032610	protein coding gene	Chr7:123238900-123256191 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033406	protein coding gene	Chr7:128321792-128343564 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030378	protein coding gene	Chr7:121685907-121704217 (+)
CAST/EiJ	MGP_CASTEiJ_G0031938	protein coding gene	Chr7:115002592-115021529 (+)
CBA/J	MGP_CBAJ_G0032583	protein coding gene	Chr7:132606732-132623951 (+)
DBA/2J	MGP_DBA2J_G0032735	protein coding gene	Chr7:118293085-118310443 (+)
FVB/NJ	MGP_FVBNJ_G0032688	protein coding gene	Chr7:118139081-118156557 (+)
LP/J	MGP_LPJ_G0032829	protein coding gene	Chr7:124896830-124917149 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032720	protein coding gene	Chr7:134076614-134095232 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033426	protein coding gene	Chr7:122323425-122341758 (+)
PWK/PhJ	MGP_PWKPhJ_G0031646	protein coding gene	Chr7:111210124-111227765 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031492	protein coding gene	Chr7:109077005-109095330 (+)
WSB/EiJ	MGP_WSBEiJ_G0032051	protein coding gene	Chr7:123228311-123248575 (+)

Human Ortholog

ACSM5, acyl-CoA synthetase medium chain family member 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSM5, acyl-CoA synthetase medium chain family member 5
Links

HGNC:26060

NCBI Gene ID: 54988

neXtProt AC: NX_Q6NUN0

UniProt: Q6NUN0
Chr Location

16p12.3; chr16:20409534-20441336 (+) GRCh38

MGI Vertebrate Homology

Acsm5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACSM5
Gene Tree

Acsm5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

97
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

8
UniProt

4
CCDS

CCDS40106.1

Ensembl

ENSMUSG00000030972 (Evidence)
NCBI Gene

272428

			Length	Strain/Species	Flank
genomic	272428	NCBI Gene Model \| MGI Sequence Detail	17230	C57BL/6J	± kb
transcript	NM_178758	RefSeq \| MGI Sequence Detail	2505	FVB/N
polypeptide	Q8BGA8	UniProt \| EBI \| MGI Sequence Detail	578	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003669 acyl-coenzyme A synthetase ACSM5, mitochondrial

(term hierarchy)
EC

6.2.1.2
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

IPR051087 Mitochondrial Acyl-CoA Synthetase Medium-Chain

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsm5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68736	Chr7:119125403-119125423 (+)	59 bp
Tssr68737	Chr7:119125425-119125441 (+)	79 bp
Tssr68738	Chr7:119125443-119125487 (+)	111 bp
Tssr68739	Chr7:119125492-119125523 (+)	154 bp
Tssr68740	Chr7:119125546-119125557 (+)	198 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24