Hecw1 MGI Mouse Gene Detail - MGI:2444115 - HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Symbol

Hecw1
Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms

E130207I19Rik, NEDL1

Feature Type

protein coding gene
IDs

MGI:2444115
NCBI Gene: 94253
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:14401023-14697813 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 5.29 cM
Mapping Data

2 experiments

SNPs within 2kb

8028 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444115	protein coding gene	Chr13:14401023-14697874 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020243	protein coding gene	Chr13:11195425-11504474 (-)
A/J	MGP_AJ_G0020201	protein coding gene	Chr13:11117621-11418661 (-)
AKR/J	MGP_AKRJ_G0020175	protein coding gene	Chr13:11242365-11556316 (-)
BALB/cJ	MGP_BALBcJ_G0020187	protein coding gene	Chr13:11099777-11393343 (-)
C3H/HeJ	MGP_C3HHeJ_G0019991	protein coding gene	Chr13:11407740-11712682 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020631	protein coding gene	Chr13:11785642-12126006 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018237	protein coding gene	Chr13:9839882-10115321 (-)
CAST/EiJ	MGP_CASTEiJ_G0019524	protein coding gene	Chr13:11065632-11377645 (-)
CBA/J	MGP_CBAJ_G0019955	protein coding gene	Chr13:12152309-12370048 (-)
DBA/2J	MGP_DBA2J_G0020074	protein coding gene	Chr13:10759351-11064827 (-)
FVB/NJ	MGP_FVBNJ_G0020055	protein coding gene	Chr13:10534752-10828962 (-)
LP/J	MGP_LPJ_G0020144	protein coding gene	Chr13:11408207-11718072 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020092	protein coding gene	Chr13:12258280-12614363 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020658	protein coding gene	Chr13:11054560-11370006 (-)
PWK/PhJ	MGP_PWKPhJ_G0019288	protein coding gene	Chr13:10856834-11149462 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019095	protein coding gene	Chr13:10217288-10526226 (-)
WSB/EiJ	MGP_WSBEiJ_G0019586	protein coding gene	Chr13:11071897-11378275 (-)

Human Ortholog

HECW1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HECW1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms

NEDL1
Links

HGNC:22195

NCBI Gene ID: 23072

neXtProt AC: NX_Q76N89

UniProt: Q76N89
Chr Location

7p14.1-p13; chr7:43112629-43566001 (+) GRCh38

MGI Vertebrate Homology

Hecw1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HECW1
Gene Tree

Hecw1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

106
cDNA Data

25
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hecw1

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All Sequences

82
RefSeq

24
UniProt

5
CCDS

CCDS49207.1

Ensembl

ENSMUSG00000021301 (Evidence)
NCBI Gene

94253

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021301	Ensembl Gene Model \| MGI Sequence Detail	296791	C57BL/6J	± kb
transcript	ENSMUST00000110516	Ensembl \| MGI Sequence Detail	9460	Not Applicable
polypeptide	ENSMUSP00000106145	Ensembl \| MGI Sequence Detail	1604	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008503 E3 ubiquitin-protein ligase HECW1

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR050409 E3 ubiquitin-protein ligase

IPR032348 E3 ubiquitin-protein ligase HECW1/2, N-terminal

IPR040524 E3 ubiquitin-protein ligase HECW1, helical box domain

IPR037795 E3 ubiquitin-protein ligase HECW, C2 domain

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR001202 WW domain

IPR036020 WW domain superfamily
GlyGen

Q8K4P8 1 site, 1 N-linked glycan (1 site)

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All nucleic 31

Genomic 4

cDNA 25

Primer pair 2

Microarray probesets 5

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MGI:2137556, MGI:2442515

Summaries

All 38

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 7
Earliest

J:70256 Martin N, et al., Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13. Genomics. 2001 Jul;75(1-3):9-16
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hecw1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121502	Chr13:14697763-14697787 (-)	38 bp
Tssr121501	Chr13:14697681-14697750 (-)	97 bp
Tssr121500	Chr13:14697611-14697622 (-)	196 bp
Tssr121499	Chr13:14697026-14697044 (-)	778 bp
Tssr121498	Chr13:14696992-14697024 (-)	805 bp
Tssr121497	Chr13:14696391-14696403 (-)	1,416 bp
Tssr121496	Chr13:14696323-14696326 (-)	1,488 bp
Tssr121495	Chr13:14493539-14493571 (-)	204,258 bp
Tssr121494	Chr13:14492573-14492601 (-)	205,226 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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