Clec1a MGI Mouse Gene Detail - MGI:2444151 - C-type lectin domain family 1, member a

Symbol

Clec1a
Name

C-type lectin domain family 1, member a
Synonyms

5930406N14Rik

Feature Type

protein coding gene
IDs

MGI:2444151
NCBI Gene: 243653
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:129403647-129428963 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 63.32 cM
Mapping Data

2 experiments

SNPs within 2kb

903 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444151	protein coding gene	Chr6:129401735-129428963 (-)
129S1/SvImJ	ENSMUSG00200045118	protein coding gene	Chr6:126508346-126535541 (-)
A/J	ENSMUSG00195028475	protein coding gene	Chr6:125926388-125953609 (-)
AKR/J	ENSMUSG00220037861	protein coding gene	Chr6:124787977-124815203 (-)
BALB/cJ	ENSMUSG00180033012	protein coding gene	Chr6:126263299-126290523 (-)
C3H/HeJ	ENSMUSG00175030473	protein coding gene	Chr6:125943527-125970746 (-)
C57BL/6NJ	ENSMUSG00215015899	protein coding gene	Chr6:126231992-126259220 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028931	protein coding gene	Chr6:126325832-126353246 (-)
CAST/EiJ	ENSTCUG00005037572	protein coding gene	Chr6:126269878-126297156 (-)
CBA/J	ENSMUSG00210016524	protein coding gene	Chr6:125963350-125990569 (-)
DBA/2J	ENSMUSG00185036941	protein coding gene	Chr6:126664112-126691331 (-)
FVB/NJ	ENSMUSG00205035261	protein coding gene	Chr6:125517832-125545100 (-)
JF1/MsJ	ENSUMUG00000021363	protein coding gene	Chr6:125279746-125307152 (-)
LP/J	ENSMUSG00230038817	protein coding gene	Chr6:127860744-127887963 (-)
NOD/ShiLtJ	ENSMUSG00190025899	protein coding gene	Chr6:125668992-125696295 (-)
NZO/HlLtJ	ENSMUSG00225015038	protein coding gene	Chr6:130130169-130175065 (-)
PWK/PhJ	ENSLUMG00010039521	protein coding gene	Chr6:124463334-124490757 (-)
SPRET/EiJ	ENSMSPG00010030815	protein coding gene	Chr6:127202198-127227622 (-)
WSB/EiJ	ENSIUOG00005043876	protein coding gene	Chr6:126386848-126414044 (-)

Human Ortholog

CLEC1A, C-type lectin domain family 1 member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC1A, C-type lectin domain family 1 member A
Synonyms

CLEC-1, CLEC1
Links

HGNC:24355

NCBI Gene ID: 51267

UniProt: Q8NC01
Chr Location

12p13.2; chr12:10069554-10111627 (-) GRCh38

MGI Vertebrate Homology

Clec1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLEC1A
Gene Tree

Clec1a

Diseases

1 with human CLEC1A associations

				Human Disease	Mouse Models
				aspergillosis IDs aspergillosis DOID:13564 ICD10CM:B44 ICD9CM:117.3 MESH:D001228 NCI:C2886 UMLS_CUI:C0004030

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Targeted

8
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a null allele exhibit decreased susceptibility to experimental autoimmune encephalomyelitis, with decreased recall memory T cell proliferation and decreased antigen-presenting ability of dendritic cells.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

674
Tissues

9
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

4
UniProt

5
CCDS

CCDS20587.1, CCDS85169.1

Ensembl

ENSMUSG00000033082 (Evidence)
NCBI Gene

243653

			Length	Strain/Species	Flank
genomic	243653	NCBI Gene Model \| MGI Sequence Detail	25317	C57BL/6J	± kb
transcript	NM_175526	RefSeq \| MGI Sequence Detail	3268	C57BL/6
polypeptide	Q8BWY2	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032425 C-type lectin domain family 1 member A

(term hierarchy)
InterPro Domains

IPR052309 C-type Lectin Domain Family 1

IPR042916 C-type lectin domain family 12 member A/B

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
GlyGen

Q8BWY2 4 sites

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 14
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:348076 Ligeron C, et al., CLEC-1 Restrains Acute Inflammatory Response and Recruitment of Neutrophils following Tissue Injury. J Immunol. 2024 Apr 1;212(7):1178-1187

TSS for Clec1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63605	Chr6:129428869-129428880 (-)	88 bp
Tssr63604	Chr6:129428836-129428847 (-)	121 bp
Tssr63603	Chr6:129428746-129428827 (-)	176 bp
Tssr63602	Chr6:129428702-129428715 (-)	254 bp
Tssr63601	Chr6:129405512-129405518 (-)	23,448 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24