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Nmnat2 Gene Detail
Summary
  • Symbol
    Nmnat2
  • Name
    nicotinamide nucleotide adenylyltransferase 2
  • Synonyms
    D030041I09Rik, mKIAA0479, PNAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444155
    NCBI Gene: 226518
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152830744-152995007 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4940 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444155
 protein coding gene Chr1:152830532-152995012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016593
 protein coding gene Chr1:157739764-157913821 (+)
A/J MGP_AJ_G0016575
 protein coding gene Chr1:151382919-151548831 (+)
AKR/J MGP_AKRJ_G0016540
 protein coding gene Chr1:156066150-156238773 (+)
BALB/cJ MGP_BALBcJ_G0016535
 protein coding gene Chr1:151957185-152116179 (+)
C3H/HeJ MGP_C3HHeJ_G0016360
 protein coding gene Chr1:156166523-156339105 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016996
 protein coding gene Chr1:163188646-163371791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014705
 protein coding gene Chr1:143698732-143862747 (+)
CAST/EiJ MGP_CASTEiJ_G0015939
 protein coding gene Chr1:155677263-155848909 (+)
CBA/J MGP_CBAJ_G0016334
 protein coding gene Chr1:168932089-169131516 (+)
DBA/2J MGP_DBA2J_G0016440
 protein coding gene Chr1:150397894-150565649 (+)
FVB/NJ MGP_FVBNJ_G0016438
 protein coding gene Chr1:148884791-149050643 (+)
LP/J MGP_LPJ_G0016511
 protein coding gene Chr1:158856446-159032414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016464
 protein coding gene Chr1:176576602-176762407 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017032
 protein coding gene Chr1:155847771-156022797 (+)
PWK/PhJ MGP_PWKPhJ_G0015725
 protein coding gene Chr1:149420751-149589800 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015512
 protein coding gene Chr1:154654732-154816794 (+)
WSB/EiJ MGP_WSBEiJ_G0016002
 protein coding gene Chr1:155907294-156079715 (+)



Homology
more
  • Human Ortholog
    NMNAT2, nicotinamide nucleotide adenylyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMNAT2, nicotinamide nucleotide adenylyltransferase 2
  • Synonyms
    C1orf15, PNAT2
  • Links
    NCBI Gene ID: 23057
    neXtProt AC: NX_Q9BZQ4
    UniProt: Q9BZQ4

  • Chr Location
    1q25.3; chr1:183248237-183418380 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 5 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap or transposon inserted allele exhibit perinatal lethality, distended bladders, atelectasis and loss of axon integrity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    961
  • Tissues
    113
  • cDNA Data
    58
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042751 Ensembl Gene Model | MGI Sequence Detail 164264 C57BL/6J ±  kb
    transcript ENSMUST00000043313 Ensembl | MGI Sequence Detail 4626 Not Applicable  
    polypeptide ENSMUSP00000041110 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011291 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
      (term hierarchy)
    • EC
      2.7.7.1, 2.7.7.18
    • InterPro Domains
      IPR004821 Cytidyltransferase-like domain
      IPR051182 Eukaryotic NMN adenylyltransferase
      IPR045094 Nicotinamide/nicotinate mononucleotide adenylyltransferase, eukaryotic
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    • GlyGen
      Q8BNJ3 2 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138339
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory