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Vps13c Gene Detail
Summary
  • Symbol
    Vps13c
  • Name
    vacuolar protein sorting 13C
  • Synonyms
    C230055H22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444207
    NCBI Gene: 320528
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:67747678-67902920 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 36.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444207
 protein coding gene Chr9:67747594-67905026 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034989
 protein coding gene Chr9:67759954-67920826 (+)
A/J MGP_AJ_G0034969
 protein coding gene Chr9:65428781-65583921 (+)
AKR/J MGP_AKRJ_G0034899
 protein coding gene Chr9:66974880-67126505 (+)
BALB/cJ MGP_BALBcJ_G0034962
 protein coding gene Chr9:65166018-65316362 (+)
C3H/HeJ MGP_C3HHeJ_G0034671
 protein coding gene Chr9:67525149-67674426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035481
 protein coding gene Chr9:69609807-69771678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032392
 protein coding gene Chr9:65057144-65215121 (+)
CAST/EiJ MGP_CASTEiJ_G0033993
 protein coding gene Chr9:67750417-67922018 (+)
CBA/J MGP_CBAJ_G0034643
 protein coding gene Chr9:72001525-72173803 (+)
DBA/2J MGP_DBA2J_G0034802
 protein coding gene Chr9:65175034-65329516 (+)
FVB/NJ MGP_FVBNJ_G0034744
 protein coding gene Chr9:64515048-64672203 (+)
LP/J MGP_LPJ_G0034884
 protein coding gene Chr9:68026945-68184956 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034786
 protein coding gene Chr9:73174014-73336042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035503
 protein coding gene Chr9:67101906-67257168 (+)
PWK/PhJ MGP_PWKPhJ_G0033697
 protein coding gene Chr9:65415200-65582150 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033530
 protein coding gene Chr9:67404635-67584989 (+)
WSB/EiJ MGP_WSBEiJ_G0034105
 protein coding gene Chr9:66996178-67157170 (+)



Homology
more
  • Human Ortholog
    VPS13C, vacuolar protein sorting 13 homolog C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS13C, vacuolar protein sorting 13 homolog C
  • Synonyms
    BLTP5C, PARK23
  • Links
    NCBI Gene ID: 54832
    neXtProt AC: NX_Q709C8
    UniProt: Q709C8

  • Chr Location
    15q22.2; chr15:61852389-62060473 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VPS13C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    23
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035284 Ensembl Gene Model | MGI Sequence Detail 155243 C57BL/6J ±  kb
    transcript ENSMUST00000077879 Ensembl | MGI Sequence Detail 11527 Not Applicable  
    polypeptide ENSMUSP00000077040 Ensembl | MGI Sequence Detail 3748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000017321 intermembrane lipid transfer protein VPS13C
      (term hierarchy)
    • InterPro Domains
      IPR015412 Atg2/VPS13, C-terminal
      IPR049424 Intermembrane lipid transfer protein VPS13, C-terminal
      IPR026847 Vacuolar protein sorting-associated protein 13
      IPR031645 Vacuolar protein sorting-associated protein 13, DH-like domain
      IPR031646 Vacuolar protein sorting-associated protein 13, extended chorein
      IPR026854 Vacuolar protein sorting-associated protein 13-like, N-terminal domain
      IPR009543 Vacuolar protein sorting-associated protein 13, VPS13 adaptor binding domain
      IPR031642 VPS13, middle RBG modules
    • GlyGen
      Q8BX70 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143091, MGI:2143255, MGI:2143453
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory