Ppp1r15b MGI Mouse Gene Detail - MGI:2444211 - protein phosphatase 1, regulatory subunit 15B

Symbol

Ppp1r15b
Name

protein phosphatase 1, regulatory subunit 15B
Synonyms

1810033K10Rik, C530022L24Rik, CReP

Feature Type

protein coding gene
IDs

MGI:2444211
NCBI Gene: 108954
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:133058904-133067538 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.80 cM
Mapping Data

2 experiments

SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444211	protein coding gene	Chr1:133058881-133067538 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016480	protein coding gene	Chr1:136653401-136662053 (+)
A/J	MGP_AJ_G0016463	protein coding gene	Chr1:131583399-131594673 (+)
AKR/J	MGP_AKRJ_G0016428	protein coding gene	Chr1:135462024-135470635 (+)
BALB/cJ	MGP_BALBcJ_G0016423	protein coding gene	Chr1:131916532-131925534 (+)
C3H/HeJ	MGP_C3HHeJ_G0016249	protein coding gene	Chr1:135600484-135609122 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016884	protein coding gene	Chr1:141722030-141732441 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014595	protein coding gene	Chr1:124737899-124746708 (+)
CAST/EiJ	MGP_CASTEiJ_G0015829	protein coding gene	Chr1:134621843-134633199 (+)
CBA/J	MGP_CBAJ_G0016221	protein coding gene	Chr1:146555546-146564009 (+)
DBA/2J	MGP_DBA2J_G0016328	protein coding gene	Chr1:130546379-130558133 (+)
FVB/NJ	MGP_FVBNJ_G0016327	protein coding gene	Chr1:129195426-129204042 (+)
LP/J	MGP_LPJ_G0016399	protein coding gene	Chr1:137962319-137973742 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016352	protein coding gene	Chr1:152323090-152332419 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016920	protein coding gene	Chr1:135209811-135218384 (+)
PWK/PhJ	MGP_PWKPhJ_G0015615	protein coding gene	Chr1:129554380-129563046 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015402	protein coding gene	Chr1:134163027-134171693 (+)
WSB/EiJ	MGP_WSBEiJ_G0015891	protein coding gene	Chr1:135211592-135223558 (+)

Human Ortholog

PPP1R15B, protein phosphatase 1 regulatory subunit 15B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R15B, protein phosphatase 1 regulatory subunit 15B
Synonyms

CREP, MSSGM2
Links

HGNC:14951

NCBI Gene ID: 84919

UniProt: Q5SWA1
Chr Location

1q32.1; chr1:204395826-204411887 (-) GRCh38

MGI Vertebrate Homology

Ppp1r15b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R15B
Gene Tree

Ppp1r15b

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
3 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

63
Chemically induced (other)

2
Gene trapped

58
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Ppp1r15b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die within the first day after birth with decreased weight at birth and red blood cell counts.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

188
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r15b

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS15291.1

Ensembl

ENSMUSG00000046062 (Evidence)
NCBI Gene

108954

			Length	Strain/Species	Flank
genomic	108954	NCBI Gene Model \| MGI Sequence Detail	8635	C57BL/6J	± kb
transcript	NM_133819	RefSeq \| MGI Sequence Detail	5588	C57BL/6
polypeptide	Q8BFW3	UniProt \| EBI \| MGI Sequence Detail	697	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013117 protein phosphatase 1 regulatory subunit 15B

(term hierarchy)
InterPro Domains

IPR051254 Protein Phosphatase 1 Regulatory Subunit 15

IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

IPR019512 Protein phosphatase 1, regulatory subunit 15B, N-terminal

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All nucleic 189

cDNA 189

Microarray probesets 4

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MGI:1920896, MGI:2138301

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353968 Kumar A, et al., 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience. Neuron. 2023 Sep 20;111(18):2831-2846.e10

TSS for Ppp1r15b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8772	Chr1:133057150-133057186 (+)	-1,736 bp
Tssr8773	Chr1:133057822-133057844 (+)	-1,071 bp
Tssr8774	Chr1:133058619-133058623 (+)	-283 bp
Tssr8775	Chr1:133058977-133058992 (+)	81 bp
Tssr8776	Chr1:133059005-133059021 (+)	109 bp
Tssr8777	Chr1:133059026-133059102 (+)	160 bp
Tssr8778	Chr1:133059107-133059120 (+)	210 bp
Tssr8779	Chr1:133059146-133059175 (+)	257 bp
Tssr8780	Chr1:133059189-133059211 (+)	296 bp
Tssr8781	Chr1:133059547-133059562 (+)	651 bp
Tssr8782	Chr1:133059960-133059973 (+)	1,063 bp
Tssr8783	Chr1:133060386-133060404 (+)	1,491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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