Map3k13 MGI Mouse Gene Detail - MGI:2444243 - mitogen-activated protein kinase kinase kinase 13

Symbol

Map3k13
Name

mitogen-activated protein kinase kinase kinase 13
Synonyms

C130026N12Rik

Feature Type

protein coding gene
IDs

MGI:2444243
NCBI Gene: 71751
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:21643923-21752189 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.92 cM
Mapping Data

1 experiment

SNPs within 2kb

3157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444243	protein coding gene	Chr16:21613096-21752189 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022662	protein coding gene	Chr16:19346620-19392482 (+)
A/J	MGP_AJ_G0022624	protein coding gene	Chr16:18415522-18455366 (+)
AKR/J	MGP_AKRJ_G0022599	protein coding gene	Chr16:19188050-19228062 (+)
BALB/cJ	MGP_BALBcJ_G0022628	protein coding gene	Chr16:18613960-18654224 (+)
C3H/HeJ	MGP_C3HHeJ_G0022393	protein coding gene	Chr16:19288070-19330893 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023079	protein coding gene	Chr16:19749486-19794690 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020597	protein coding gene	Chr16:19119708-19158792 (+)
CAST/EiJ	MGP_CASTEiJ_G0021923	protein coding gene	Chr16:19276120-19315344 (+)
CBA/J	MGP_CBAJ_G0022365	protein coding gene	Chr16:20574613-20617300 (+)
DBA/2J	MGP_DBA2J_G0022497	protein coding gene	Chr16:18400836-18441279 (+)
FVB/NJ	MGP_FVBNJ_G0022472	protein coding gene	Chr16:18371424-18411046 (+)
LP/J	MGP_LPJ_G0022564	protein coding gene	Chr16:19093382-19141460 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022492	protein coding gene	Chr16:20170888-20217970 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023090	protein coding gene	Chr16:19131737-19171462 (+)
PWK/PhJ	MGP_PWKPhJ_G0021663	protein coding gene	Chr16:18634711-18675557 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021493	protein coding gene	Chr16:18912895-18956190 (+)
WSB/EiJ	MGP_WSBEiJ_G0021966	protein coding gene	Chr16:19095053-19141108 (+)

Human Ortholog

MAP3K13, mitogen-activated protein kinase kinase kinase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K13, mitogen-activated protein kinase kinase kinase 13
Synonyms

LZK, MEKK13, MLK
Links

HGNC:6852

NCBI Gene ID: 9175

neXtProt AC: NX_O43283

UniProt: O43283
Chr Location

3q27.2; chr3:185282941-185489094 (+) GRCh38

MGI Vertebrate Homology

Map3k13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K13
Protein SuperFamily

MAPKKK12_MAPKKK13
Gene Tree

Map3k13

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no overt developmental defect in cerebellar formation.

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

18
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map3k13

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All Sequences

47
RefSeq

12
UniProt

1
CCDS

CCDS37294.1

Ensembl

ENSMUSG00000033618 (Evidence)
NCBI Gene

71751

			Length	Strain/Species	Flank
genomic	71751	NCBI Gene Model \| MGI Sequence Detail	108267	C57BL/6J	± kb
transcript	NM_172821	RefSeq \| MGI Sequence Detail	6709	C57BL/6
polypeptide	Q1HKZ5	UniProt \| EBI \| MGI Sequence Detail	959	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010132 mitogen-activated protein kinase kinase kinase 13

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR017419 Mitogen-activated protein kinase kinase kinase 12/13

IPR027258 Mitogen-activated protein kinase kinase kinase 13

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050167 Serine/threonine-protein kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Map3k13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137521	Chr16:21644767-21644795 (+)	858 bp
Tssr137522	Chr16:21654720-21654723 (+)	10,799 bp
Tssr137523	Chr16:21673860-21673876 (+)	29,945 bp
Tssr137524	Chr16:21673877-21673892 (+)	29,962 bp
Tssr137525	Chr16:21673895-21673916 (+)	29,983 bp
Tssr137526	Chr16:21686722-21686731 (+)	42,804 bp
Tssr137528	Chr16:21749806-21749809 (+)	105,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24