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Glis3 Gene Detail
Summary
  • Symbol
    Glis3
  • Name
    GLIS family zinc finger 3
  • Synonyms
    4833409N03Rik, E330013K21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444289
    NCBI Gene: 226075
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:28236251-28657477 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 22.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444289
 protein coding gene Chr19:28236251-28657684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025011
 protein coding gene Chr19:26661064-27097052 (-)
A/J MGP_AJ_G0024988
 protein coding gene Chr19:25297632-25719313 (-)
AKR/J MGP_AKRJ_G0024956
 protein coding gene Chr19:26243357-26663402 (-)
BALB/cJ MGP_BALBcJ_G0024987
 protein coding gene Chr19:25332326-25763908 (-)
C3H/HeJ MGP_C3HHeJ_G0024743
 protein coding gene Chr19:26186111-26623110 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025428
 protein coding gene Chr19:27409756-27847682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022847
 protein coding gene Chr19:25289422-25710776 (-)
CAST/EiJ MGP_CASTEiJ_G0024213
 protein coding gene Chr19:26004757-26451576 (-)
CBA/J MGP_CBAJ_G0024721
 protein coding gene Chr19:28706187-29162013 (-)
DBA/2J MGP_DBA2J_G0024853
 protein coding gene Chr19:25263578-25685681 (-)
FVB/NJ MGP_FVBNJ_G0024815
 protein coding gene Chr19:25112450-25533782 (-)
LP/J MGP_LPJ_G0024938
 protein coding gene Chr19:26642557-27089197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024842
 protein coding gene Chr19:28656393-29100370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025483
 protein coding gene Chr19:26243884-26674362 (-)
PWK/PhJ MGP_PWKPhJ_G0023961
 protein coding gene Chr19:24910122-25342411 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023765
 protein coding gene Chr19:25489471-25926882 (-)
WSB/EiJ MGP_WSBEiJ_G0024280
 protein coding gene Chr19:26278212-26710020 (-)



Homology
more
  • Human Ortholog
    GLIS3, GLIS family zinc finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLIS3, GLIS family zinc finger 3
  • Synonyms
    NDH, ZNF515
  • Links
    NCBI Gene ID: 169792
    neXtProt AC: NX_Q8NEA6
    UniProt: Q8NEA6

  • Chr Location
    9p24.2; chr9:3824127-4490465 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Glis3 mouse models; 1 with human GLIS3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    85
  • cDNA Data
    10
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052942 Ensembl Gene Model | MGI Sequence Detail 421227 C57BL/6J ±  kb
    transcript ENSMUST00000162022 Ensembl | MGI Sequence Detail 7514 Not Applicable  
    polypeptide ENSMUSP00000124635 Ensembl | MGI Sequence Detail 935 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918872
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:352715 Kang HS, et al., GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory