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Nalcn Gene Detail
Summary
  • Symbol
    Nalcn
  • Name
    sodium leak channel, non-selective
  • Synonyms
    A530023G15Rik, Vgcnl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444306
    NCBI Gene: 338370
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr14:123514046-123864556 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 66.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6633 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444306
 protein coding gene Chr14:123514046-123864846 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021677
 protein coding gene Chr14:121214333-121570878 (-)
A/J MGP_AJ_G0021637
 protein coding gene Chr14:116529141-116868642 (-)
AKR/J MGP_AKRJ_G0021613
 protein coding gene Chr14:120284499-120628823 (-)
BALB/cJ MGP_BALBcJ_G0021643
 protein coding gene Chr14:117086925-117415973 (-)
C3H/HeJ MGP_C3HHeJ_G0021420
 protein coding gene Chr14:120183713-120527016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022083
 protein coding gene Chr14:125851199-126216979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019621
 protein coding gene Chr14:112313215-112630771 (-)
CAST/EiJ MGP_CASTEiJ_G0020936
 protein coding gene Chr14:118065874-118416326 (-)
CBA/J MGP_CBAJ_G0021389
 protein coding gene Chr14:130657078-131042478 (-)
DBA/2J MGP_DBA2J_G0021512
 protein coding gene Chr14:116360857-116741114 (-)
FVB/NJ MGP_FVBNJ_G0021490
 protein coding gene Chr14:114714789-115051824 (-)
LP/J MGP_LPJ_G0021580
 protein coding gene Chr14:122115804-122473632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021517
 protein coding gene Chr14:135623273-136031686 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022106
 protein coding gene Chr14:119849872-120200207 (-)
PWK/PhJ MGP_PWKPhJ_G0020680
 protein coding gene Chr14:113415109-113760256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020518
 protein coding gene Chr14:116080904-116397767 (-)
WSB/EiJ MGP_WSBEiJ_G0020992
 protein coding gene Chr14:120538998-120869740 (-)



Homology
more
  • Human Ortholog
    NALCN, sodium leak channel, non-selective
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NALCN, sodium leak channel, non-selective
  • Synonyms
    bA430M15.1, CanIon, CLIFAHDD, IHPRF, IHPRF1, INNFD, VGCNL1
  • Links
    NCBI Gene ID: 259232
    neXtProt AC: NX_Q8IZF0
    UniProt: Q8IZF0

  • Chr Location
    13q32.3-q33.1; chr13:101053776-101417179 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NALCN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    10
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000197 Ensembl Gene Model | MGI Sequence Detail 350511 C57BL/6J ±  kb
    transcript ENSMUST00000000201 Ensembl | MGI Sequence Detail 7122 Not Applicable  
    polypeptide ENSMUSP00000000201 Ensembl | MGI Sequence Detail 1739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3034847
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:349019 Ngodup T, et al., The Na(+) leak channel NALCN controls spontaneous activity and mediates synaptic modulation by alpha2-adrenergic receptors in auditory neurons. Elife. 2024 Jan 10;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory