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Strip2 Gene Detail
Summary
  • Symbol
    Strip2
  • Name
    striatin interacting protein 2
  • Synonyms
    D330017J20Rik, Fam40b, mKIAA1170, Myoscape
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444363
    NCBI Gene: 320609
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29917011-29959680 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1026 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444363
 protein coding gene Chr6:29916975-29959680 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030532
 protein coding gene Chr6:27755496-27799906 (+)
A/J MGP_AJ_G0030505
 protein coding gene Chr6:26576045-26618436 (+)
AKR/J MGP_AKRJ_G0030432
 protein coding gene Chr6:27449676-27492024 (+)
BALB/cJ MGP_BALBcJ_G0030515
 protein coding gene Chr6:26733547-26776301 (+)
C3H/HeJ MGP_C3HHeJ_G0030228
 protein coding gene Chr6:27457400-27499833 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030969
 protein coding gene Chr6:28536768-28585646 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028180
 protein coding gene Chr6:24777997-24821074 (+)
CAST/EiJ MGP_CASTEiJ_G0029630
 protein coding gene Chr6:27256287-27299602 (+)
CBA/J MGP_CBAJ_G0030206
 protein coding gene Chr6:29623844-29669155 (+)
DBA/2J MGP_DBA2J_G0030350
 protein coding gene Chr6:26510609-26553436 (+)
FVB/NJ MGP_FVBNJ_G0030304
 protein coding gene Chr6:26268440-26311172 (+)
LP/J MGP_LPJ_G0030437
 protein coding gene Chr6:27892901-27937831 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030340
 protein coding gene Chr6:32108065-32151626 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030999
 protein coding gene Chr6:27334653-27377086 (+)
PWK/PhJ MGP_PWKPhJ_G0029344
 protein coding gene Chr6:26067986-26111532 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029180
 protein coding gene Chr6:27062052-27105112 (+)
WSB/EiJ MGP_WSBEiJ_G0029706
 protein coding gene Chr6:27296884-27339813 (+)



Homology
more
  • Human Ortholog
    STRIP2, striatin interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRIP2, striatin interacting protein 2
  • Synonyms
    FAM40B, FAR11B
  • Links
    NCBI Gene ID: 57464
    neXtProt AC: NX_Q9ULQ0
    UniProt: Q9ULQ0

  • Chr Location
    7q32.1; chr7:129434432-129488399 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects cardiac muscle contractility under basal conditions and worsening pulmonary congestion and cardiac phenotypes (muscle contractility reduction, hypertrophy, fibrosis) under pressure overload.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039629 Ensembl Gene Model | MGI Sequence Detail 42670 C57BL/6J ±  kb
    transcript ENSMUST00000046028 Ensembl | MGI Sequence Detail 5370 Not Applicable  
    polypeptide ENSMUSP00000036477 Ensembl | MGI Sequence Detail 844 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory