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Gbp7 Gene Detail
Summary
  • Symbol
    Gbp7
  • Name
    guanylate binding protein 7
  • Synonyms
    9830147J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444421
    NCBI Gene: 229900
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142236103-142255910 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    668 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444421
 protein coding gene Chr3:142236097-142255912 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027942
 protein coding gene Chr3:145715556-145738280 (+)
A/J MGP_AJ_G0027899
 protein coding gene Chr3:140559726-140580403 (+)
AKR/J MGP_AKRJ_G0027865
 protein coding gene Chr3:144268751-144289795 (+)
BALB/cJ MGP_BALBcJ_G0027911
 protein coding gene Chr3:140363867-140383237 (+)
C3H/HeJ MGP_C3HHeJ_G0027641
 protein coding gene Chr3:144621695-144642699 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028355
 protein coding gene Chr3:150789894-150811964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025693
 protein coding gene Chr3:135796219-135816107 (+)
CAST/EiJ MGP_CASTEiJ_G0027096
 protein coding gene Chr3:144541820-144562939 (+)
CBA/J MGP_CBAJ_G0027618
 protein coding gene Chr3:155977988-156000051 (+)
DBA/2J MGP_DBA2J_G0027757
 protein coding gene Chr3:139690288-139710495 (+)
FVB/NJ MGP_FVBNJ_G0027724
 protein coding gene Chr3:137113149-137133525 (+)
LP/J MGP_LPJ_G0027867
 protein coding gene Chr3:147149311-147169353 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027756
 protein coding gene Chr3:164295869-164319992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028413
 protein coding gene Chr3:143886212-143907466 (+)
PWK/PhJ MGP_PWKPhJ_G0026821
 protein coding gene Chr3:139502946-139523312 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026648
 protein coding gene Chr3:142007911-142028605 (+)
WSB/EiJ MGP_WSBEiJ_G0027176
 protein coding gene Chr3:144743330-144764251 (+)



Homology
more
  • Human Ortholog
    GBP7, guanylate binding protein 7
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP7, guanylate binding protein 7
  • Synonyms
    GBP4L
  • Links
    NCBI Gene ID: 388646
    neXtProt AC: NX_Q8N8V2
    UniProt: Q8N8V2

  • Chr Location
    1p22.2; chr1:89131742-89176009 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    83
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040253 Ensembl Gene Model | MGI Sequence Detail 19808 C57BL/6J ±  kb
    transcript ENSMUST00000045097 Ensembl | MGI Sequence Detail 5614 Not Applicable  
    polypeptide ENSMUSP00000049104 Ensembl | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      3.6.1.-, 3.6.5.-
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR037684 Guanylate-binding protein, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 83

      Microarray probesets 4
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:350745 Marinho FV, et al., Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection. Front Immunol. 2024;15:1341464
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory