early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
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| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Pas15 | Chr6, syntenic | Chr6:145180868-145181064 | J:90940 | The Pas15 lung tumor susceptibility locus was localized to a 486 kb region on mouse Chromosome 6 by fine mapping of the recombinant congenic (RC) strain CXB5/ByJ. CXB5/ByJ is derived from BALB/cJ and C57BL/6J progenitor strains and is highly resistant to lung tumor development. Genotyping of 65 markers in 29 inbred strains for a 1 Mb region around Pas15 revealed a core haplotype that is either C57BL/6-derived or A/J-derived. The Pas1 critical region contains 6 candidate genes: Bcat1, Lrmp, Kras, Casc1, 4933403M22Rik, and 4930469P12Rik. In lung tumors from (A/J x C57BL/6J)F1 mice, Casc1 appears to be expressed solely from the A/J allele and expression of 4933403M22Rik appears to be completely downregulated. |
| Pas15 | Chr6, syntenic | Chr6:145180868-145181064 | J:108212 | Previously identified QTL Pas15 (pulmonary adenoma susceptibility 1) maps to a 468 kb interval on mouse Chromosome 6. This region contains six candidate genes: Lrmp, Casc1, 4930469P12Rik (aka Ghiso), and 4933403M22Rik (aka Lmna-rs1). Allele-specific expression constructs of each of the candidate genes were derived from lung mRNA from inbred strains A/J (pulmonary adenoma susceptible) and C57BL/6J (pulmonary adenoma resistant). The expression constructs were transfected into 2 human small-cell lung carcinoma cell lines and assayed for transformation. The ability of Lrmp and 4930469P12Rik constructs to transform human lung carcinoma cells did not differ between A/J and C57BL/6J alleles. However, the A/J allele of Casc1 produced fewer transformed human cells compared to the C57BL/6J allele, and the A/J allele of 4933403M22Rik produced more transformed human cells compared to the C57BL/6J allele. Casc1 was observed preferentially expressed in lung tumors of the A/J-derived allele. 4933403M22Rik expression was not observed in mouse lung tumors of any genotype. Authors state that the experimental results do not necessarily preclude Lrmp and 4930469P12Rik as candidate genes for Pas1. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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