Mtcl2 MGI Mouse Gene Detail - MGI:2444575 - microtubule crosslinking factor 2

Symbol

Mtcl2
Name

microtubule crosslinking factor 2
Synonyms

9830001H06Rik, D430036N24Rik, Soga1

Feature Type

protein coding gene
IDs

MGI:2444575
NCBI Gene: 320706
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:156857719-156921174 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.91 cM
Mapping Data

2 experiments

SNPs within 2kb

1826 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444575	protein coding gene	Chr2:156852361-156921185 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026774	protein coding gene	Chr2:161986591-162054204 (-)
A/J	MGP_AJ_G0026740	protein coding gene	Chr2:155515604-155578585 (-)
AKR/J	MGP_AKRJ_G0026711	protein coding gene	Chr2:160081228-160154292 (-)
BALB/cJ	MGP_BALBcJ_G0026749	protein coding gene	Chr2:155798190-155863875 (-)
C3H/HeJ	MGP_C3HHeJ_G0026491	protein coding gene	Chr2:160390360-160454469 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027198	protein coding gene	Chr2:166759761-166826282 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024568	protein coding gene	Chr2:148975100-149038790 (-)
CAST/EiJ	MGP_CASTEiJ_G0025953	protein coding gene	Chr2:160729930-160800251 (-)
CBA/J	MGP_CBAJ_G0026468	protein coding gene	Chr2:172804073-172875846 (-)
DBA/2J	MGP_DBA2J_G0026606	protein coding gene	Chr2:154684964-154750806 (-)
FVB/NJ	MGP_FVBNJ_G0026573	protein coding gene	Chr2:153077039-153145102 (-)
LP/J	MGP_LPJ_G0026711	protein coding gene	Chr2:162081724-162148933 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026594	protein coding gene	Chr2:176653370-176719464 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027254	protein coding gene	Chr2:159903561-159967959 (-)
PWK/PhJ	MGP_PWKPhJ_G0025687	protein coding gene	Chr2:154194040-154259381 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025490	protein coding gene	Chr2:158847966-158916952 (-)
WSB/EiJ	MGP_WSBEiJ_G0026023	protein coding gene	Chr2:160787433-160856853 (-)

Human Ortholog

MTCL2, microtubule crosslinking factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTCL2, microtubule crosslinking factor 2
Synonyms

C20orf117, KIAA0889, SOGA, SOGA1
Links

HGNC:16111

NCBI Gene ID: 140710

neXtProt AC: NX_O94964

UniProt: O94964
Chr Location

20q11.23; chr20:36777447-36863538 (-) GRCh38

MGI Vertebrate Homology

Mtcl2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MTCL2
Gene Tree

Mtcl2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

7
Targeted

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

102

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtcl2

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All Sequences

48
RefSeq

6
UniProt

4
CCDS

CCDS50781.1

Ensembl

ENSMUSG00000055485 (Evidence)
NCBI Gene

320706

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055485	Ensembl Gene Model \| MGI Sequence Detail	63456	C57BL/6J	± kb
transcript	ENSMUST00000069098	Ensembl \| MGI Sequence Detail	7864	Not Applicable
polypeptide	ENSMUSP00000066556	Ensembl \| MGI Sequence Detail	1654	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032663 microtubule cross-linking factor 2

(term hierarchy)
InterPro Domains

IPR049885 Microtubule cross-linking factor 1-3

IPR027882 SOGA 1/2-like, coiled-coil

IPR027881 SOGA, coiled-coil domain

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All nucleic 102

cDNA 102

Microarray probesets 5

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MGI:2138932, MGI:7525413

Summaries

All 38

Gene Ontology 7

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:340658 Kruse R, et al., Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein. Mol Cell Proteomics. 2017 Oct;16(10):1718-1735

TSS for Mtcl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27103	Chr2:156921554-156921599 (-)	-403 bp
Tssr27102	Chr2:156921251-156921274 (-)	-89 bp
Tssr27101	Chr2:156921132-156921196 (-)	10 bp
Tssr27100	Chr2:156921117-156921129 (-)	51 bp
Tssr27099	Chr2:156921044-156921069 (-)	117 bp
Tssr27098	Chr2:156921001-156921041 (-)	153 bp
Tssr27097	Chr2:156900678-156900691 (-)	20,489 bp
Tssr27096	Chr2:156900648-156900673 (-)	20,513 bp
Tssr27095	Chr2:156900639-156900645 (-)	20,532 bp
Tssr27094	Chr2:156899837-156899877 (-)	21,317 bp
Tssr27093	Chr2:156869713-156869724 (-)	51,455 bp
Tssr27092	Chr2:156869669-156869678 (-)	51,500 bp
Tssr27091	Chr2:156867953-156867957 (-)	53,219 bp
Tssr27090	Chr2:156859451-156859455 (-)	61,721 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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