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Abi3bp Gene Detail
Summary
  • Symbol
    Abi3bp
  • Name
    ABI family member 3 binding protein
  • Synonyms
    5033411B22Rik, D930038M13Rik, eratin, TARSH
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444583
    NCBI Gene: 320712
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56298241-56510498 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444583
 protein coding gene Chr16:56298179-56510498 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022889
 protein coding gene Chr16:55588769-55823669 (+)
A/J MGP_AJ_G0022856
 protein coding gene Chr16:53201961-53420864 (+)
AKR/J MGP_AKRJ_G0022828
 protein coding gene Chr16:54898354-55111188 (+)
BALB/cJ MGP_BALBcJ_G0022856
 protein coding gene Chr16:53303515-53525239 (+)
C3H/HeJ MGP_C3HHeJ_G0022619
 protein coding gene Chr16:55085656-55303242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023304
 protein coding gene Chr16:57174692-57411109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020815
 protein coding gene Chr16:52890206-53102012 (+)
CAST/EiJ MGP_CASTEiJ_G0022146
 protein coding gene Chr16:55459625-55695235 (+)
CBA/J MGP_CBAJ_G0022592
 protein coding gene Chr16:59459045-59699168 (+)
DBA/2J MGP_DBA2J_G0022724
 protein coding gene Chr16:52966632-53181669 (+)
FVB/NJ MGP_FVBNJ_G0022699
 protein coding gene Chr16:52730315-52947115 (+)
LP/J MGP_LPJ_G0022791
 protein coding gene Chr16:55415366-55640283 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022717
 protein coding gene Chr16:59772066-60027235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023319
 protein coding gene Chr16:55064151-55286145 (+)
PWK/PhJ MGP_PWKPhJ_G0021885
 protein coding gene Chr16:53289286-53502875 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021715
 protein coding gene Chr16:54803535-55033749 (+)
WSB/EiJ MGP_WSBEiJ_G0022190
 protein coding gene Chr16:55081650-55307871 (+)



Homology
more
  • Human Ortholog
    ABI3BP, ABI family member 3 binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABI3BP, ABI family member 3 binding protein
  • Synonyms
    NESHBP, TARSH
  • Links
    NCBI Gene ID: 25890
    neXtProt AC: NX_Q7Z7G0
    UniProt: Q7Z7G0

  • Chr Location
    3q12.2; chr3:100749156-100993515 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show no major changes in anxiety, depression-like behavior, olfactory function or tumor incidence. Homozygotes for a different null allele show reduced cardiac progenitor cell (CPC) differentiation, increased CPC proliferation, and susceptibility to myocardial injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    22
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035258 Ensembl Gene Model | MGI Sequence Detail 212258 C57BL/6J ±  kb
    transcript ENSMUST00000231781 Ensembl | MGI Sequence Detail 5196 Not Applicable  
    polypeptide ENSMUSP00000156096 Ensembl | MGI Sequence Detail 1637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR049109 Target of Nesh-SH3/FNDC1, C-terminal domain
    • GlyGen
      A0A338P6S8 11 sites, 11 N-linked glycans (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146450, MGI:2668157
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory