Sh3rf2 MGI Mouse Gene Detail - MGI:2444628 - SH3 domain containing ring finger 2

Symbol

Sh3rf2
Name

SH3 domain containing ring finger 2
Synonyms

9130023G24Rik, RNF158

Feature Type

protein coding gene
IDs

MGI:2444628
NCBI Gene: 269016
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:42186732-42292025 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 22.21 cM
Mapping Data

2 experiments

SNPs within 2kb

3102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444628	protein coding gene	Chr18:42185531-42292025 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024375	protein coding gene	Chr18:40657547-40775744 (+)
A/J	MGP_AJ_G0024342	protein coding gene	Chr18:39259751-39372845 (+)
AKR/J	MGP_AKRJ_G0024311	protein coding gene	Chr18:40340357-40451349 (+)
BALB/cJ	MGP_BALBcJ_G0024342	protein coding gene	Chr18:39332971-39444646 (+)
C3H/HeJ	MGP_C3HHeJ_G0024108	protein coding gene	Chr18:40389224-40503912 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024784	protein coding gene	Chr18:42105289-42238456 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022223	protein coding gene	Chr18:39084971-39190536 (+)
CAST/EiJ	MGP_CASTEiJ_G0023583	protein coding gene	Chr18:40340059-40461882 (+)
CBA/J	MGP_CBAJ_G0024078	protein coding gene	Chr18:43364738-43481518 (+)
DBA/2J	MGP_DBA2J_G0024208	protein coding gene	Chr18:38844594-38953387 (+)
FVB/NJ	MGP_FVBNJ_G0024174	protein coding gene	Chr18:38485370-38593044 (+)
LP/J	MGP_LPJ_G0024292	protein coding gene	Chr18:40727652-40844297 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024205	protein coding gene	Chr18:44621111-44744835 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024833	protein coding gene	Chr18:40217665-40327488 (+)
PWK/PhJ	MGP_PWKPhJ_G0023327	protein coding gene	Chr18:39058285-39171741 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023132	protein coding gene	Chr18:40450991-40562745 (+)
WSB/EiJ	MGP_WSBEiJ_G0023646	protein coding gene	Chr18:40133063-40234275 (+)

Human Ortholog

SH3RF2, SH3 domain containing ring finger 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3RF2, SH3 domain containing ring finger 2
Synonyms

HEPP1, POSHER, PPP1R39, RNF158
Links

HGNC:26299

NCBI Gene ID: 153769

neXtProt AC: NX_Q8TEC5

UniProt: Q8TEC5
Chr Location

5q32; chr5:145936578-146081791 (+) GRCh38

MGI Vertebrate Homology

Sh3rf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH3RF2
Gene Tree

Sh3rf2

Diseases

1 with Sh3rf2 mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

6
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

36
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

16
cDNA Data

32
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS29210.1, CCDS50265.1

Ensembl

ENSMUSG00000057719 (Evidence)
NCBI Gene

269016

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057719	Ensembl Gene Model \| MGI Sequence Detail	105294	C57BL/6J	± kb
transcript	ENSMUST00000072008	Ensembl \| MGI Sequence Detail	5092	Not Applicable
polypeptide	ENSMUSP00000071896	Ensembl \| MGI Sequence Detail	735	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030351 E3 ubiquitin-protein ligase SH3RF2

(term hierarchy)
PDB

2CUC, 2DJQ
EC

2.3.2.27
InterPro Domains

IPR035792 E3 ubiquitin-protein ligase SH3RF2, first SH3 domain

IPR028511 E3 ubiquitin-protein ligase SH3RF2, RING finger, HC subclass

IPR035794 E3 ubiquitin-protein ligase SH3RF2, second SH3 domain

IPR050384 Endophilin/SH3RF

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035822 SH3RF2, third SH3 domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site
GlyGen

Q8BZT2 1 site, 1 N-linked glycan (1 site)

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All nucleic 32

cDNA 32

Microarray probesets 3

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MGI:2147232

Summaries

All 34

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh3rf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5297	Chr18:42185520-42185531 (+)	-1,206 bp
Tssr150863	Chr18:42185540-42185552 (+)	-1,186 bp
Tssr150864	Chr18:42186713-42186727 (+)	-12 bp
Tssr150865	Chr18:42186740-42186754 (+)	15 bp
Tssr150866	Chr18:42186757-42186789 (+)	41 bp
Tssr150867	Chr18:42186792-42186803 (+)	66 bp
Tssr150868	Chr18:42274967-42274984 (+)	88,244 bp
Tssr150869	Chr18:42276092-42276104 (+)	89,366 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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