Adam6b MGI Mouse Gene Detail - MGI:2444636 - a disintegrin and metallopeptidase domain 6B

Symbol

Adam6b
Name

a disintegrin and metallopeptidase domain 6B
Synonyms

4930523C11Rik

Feature Type

protein coding gene
IDs

MGI:2444636
NCBI Gene: 238405
Alliance

gene page

Sequence Map

Chr12:113453185-113455455 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 62.10 cM
Mapping Data

1 experiment

SNPs within 2kb

33 from dbSNP Build 142
Strain Annotations

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444636	protein coding gene	Chr12:113453131-113455677 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020176	protein coding gene	Chr12:116045582-116048235 (+)
A/J	MGP_AJ_G0020133	protein coding gene	Chr12:111549132-111551784 (+)
AKR/J	MGP_AKRJ_G0020108	protein coding gene	Chr12:114840939-114843485 (+)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0019920	protein coding gene	Chr12:115307300-115377670 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020563	protein coding gene	Chr12:119645347-119647893 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019460	protein coding gene	Chr12:110256340-110259775 (+)
CBA/J	MGP_CBAJ_G0019887	protein coding gene	Chr12:124230744-124233705 (+)
DBA/2J	MGP_DBA2J_G0020003	protein coding gene	Chr12:111042415-111045065 (+)
FVB/NJ	MGP_FVBNJ_G0019988	protein coding gene	Chr12:109872886-109875537 (+)
LP/J	MGP_LPJ_G0020078	protein coding gene	Chr12:115895505-115898051 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0020592	protein coding gene	Chr12:114291728-114294383 (+)
PWK/PhJ	MGP_PWKPhJ_G0019221	protein coding gene	Chr12:105769702-105776396 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019026	protein coding gene	Chr12:108476797-108479001 (+)
WSB/EiJ	no annotation

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MGI Vertebrate Homology

Adam6b stringent orthology
1 mouse;1 rat
Gene Tree

Adam6b

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Phenotype Summary

1 phenotype from multigenic genotypes
5 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

3 involving Adam6b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for null alleles of Adam6a and Adam6b exhibit severely reduced male fertility associated with impaired sperm to sperm interactions and sperm binding to zona pellucida.

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All GO Annotations

6
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

3
UniProt

5
CCDS

CCDS26207.1

Ensembl

ENSMUSG00000051804 (Evidence)
NCBI Gene

238405

			Length	Strain/Species	Flank
genomic	238405	NCBI Gene Model \| MGI Sequence Detail	2271	C57BL/6J	± kb
transcript	NM_001009545	RefSeq \| MGI Sequence Detail	2271	Not Specified
polypeptide	NP_001009545	RefSeq \| MGI Sequence Detail	756	Not Specified

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UniProt

5 Sequences
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR000742 EGF-like domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 4

Summaries

All 23

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:284593 Skokos D, et al., A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Sci Transl Med. 2020 Jan 8;12(525)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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