Fbxo38 MGI Mouse Gene Detail - MGI:2444639

Symbol

Fbxo38
Name

F-box protein 38
Synonyms

6030410I24Rik, SP329

Feature Type

protein coding gene
IDs

MGI:2444639
NCBI Gene: 107035
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:62637226-62681766 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 35.11 cM
Mapping Data

2 experiments

SNPs within 2kb

1377 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444639	protein coding gene	Chr18:62637130-62681934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024491	protein coding gene	Chr18:62448122-62492735 (-)
A/J	MGP_AJ_G0024458	protein coding gene	Chr18:59765417-59810798 (-)
AKR/J	MGP_AKRJ_G0024428	protein coding gene	Chr18:61418419-61464911 (-)
BALB/cJ	MGP_BALBcJ_G0024457	protein coding gene	Chr18:59899546-59944929 (-)
C3H/HeJ	MGP_C3HHeJ_G0024225	protein coding gene	Chr18:61655841-61701451 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024904	protein coding gene	Chr18:64134109-64178785 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022335	protein coding gene	Chr18:59287675-59334985 (-)
CAST/EiJ	MGP_CASTEiJ_G0023698	protein coding gene	Chr18:61526762-61572233 (-)
CBA/J	MGP_CBAJ_G0024195	protein coding gene	Chr18:66206717-66252140 (-)
DBA/2J	MGP_DBA2J_G0024325	protein coding gene	Chr18:59434073-59478675 (-)
FVB/NJ	MGP_FVBNJ_G0024291	protein coding gene	Chr18:58836657-58882137 (-)
LP/J	MGP_LPJ_G0024409	protein coding gene	Chr18:62323189-62369031 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024320	protein coding gene	Chr18:67758494-67806215 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024951	protein coding gene	Chr18:61620080-61665908 (-)
PWK/PhJ	MGP_PWKPhJ_G0023441	protein coding gene	Chr18:59663120-59708824 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023247	protein coding gene	Chr18:61844952-61891843 (-)
WSB/EiJ	MGP_WSBEiJ_G0023762	protein coding gene	Chr18:61483547-61528396 (-)

Human Ortholog

FBXO38, F-box protein 38

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO38, F-box protein 38
Synonyms

Fbx38, HMN2D, HMND6, MOKA, SP329
Links

HGNC:28844

NCBI Gene ID: 81545

neXtProt AC: NX_Q6PIJ6

UniProt: Q6PIJ6
Chr Location

5q32; chr5:148383935-148442836 (+) GRCh38

MGI Vertebrate Homology

Fbxo38 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO38
Gene Tree

Fbxo38

Diseases

1 with human FBXO38 associations

				Human Disease	Mouse Models
				autosomal dominant distal hereditary motor neuronopathy 6 IDs autosomal dominant distal hereditary motor neuronopathy 6 DOID:0111210 OMIM:615575

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Gene trapped

12
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit incomplete prenatal lethality, defective in Sertoli cell maturation, delayed first wave of spermatogenesis, oligospermia, and reduced male fertility

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

51
cDNA Data

133
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo38

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All Sequences

85
RefSeq

38
UniProt

4
CCDS

CCDS37841.1

Ensembl

ENSMUSG00000042211 (Evidence)
NCBI Gene

107035

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042211	Ensembl Gene Model \| MGI Sequence Detail	44541	C57BL/6J	± kb
transcript	ENSMUST00000048688	Ensembl \| MGI Sequence Detail	4254	Not Applicable
polypeptide	ENSMUSP00000047541	Ensembl \| MGI Sequence Detail	1194	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007406 F-box only protein 38

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR042354 F-box only protein 38

IPR032675 Leucine-rich repeat domain superfamily
GlyGen

Q8BMI0 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 135

cDNA 134

Other 1

Microarray probesets 3

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MGI:2147329, MGI:2147357

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326445 Dibus N, et al., FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Front Cell Dev Biol. 2022;10:914053

TSS for Fbxo38:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153629	Chr18:62681951-62681965 (-)	-192 bp
Tssr153628	Chr18:62681924-62681949 (-)	-171 bp
Tssr153627	Chr18:62681792-62681836 (-)	-48 bp
Tssr153626	Chr18:62681753-62681788 (-)	-5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24