Tfcp2l1 MGI Mouse Gene Detail - MGI:2444691 - transcription factor CP2-like 1

Symbol

Tfcp2l1
Name

transcription factor CP2-like 1
Synonyms

1810030F05Rik, 4932442M07Rik, Cp2l1, Crtr-1, D930018N21Rik, LBP-9, Tcfcp2l1

Feature Type

protein coding gene
IDs

MGI:2444691
NCBI Gene: 81879
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:118555675-118612898 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.14 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

1440 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444691	protein coding gene	Chr1:118555646-118612898 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016392	protein coding gene	Chr1:121323680-121389193 (+)
A/J	MGP_AJ_G0016375	protein coding gene	Chr1:116993506-117052555 (+)
AKR/J	MGP_AKRJ_G0016340	protein coding gene	Chr1:120449556-120509894 (+)
BALB/cJ	MGP_BALBcJ_G0016335	protein coding gene	Chr1:117252267-117312444 (+)
C3H/HeJ	MGP_C3HHeJ_G0016161	protein coding gene	Chr1:120621174-120680190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016796	protein coding gene	Chr1:125981488-126040966 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014509	protein coding gene	Chr1:110667256-110726741 (+)
CAST/EiJ	MGP_CASTEiJ_G0015742	protein coding gene	Chr1:119347466-119412776 (+)
CBA/J	MGP_CBAJ_G0016134	protein coding gene	Chr1:130326607-130400115 (+)
DBA/2J	MGP_DBA2J_G0016240	protein coding gene	Chr1:116007571-116065080 (+)
FVB/NJ	MGP_FVBNJ_G0016239	protein coding gene	Chr1:114737274-114796547 (+)
LP/J	MGP_LPJ_G0016311	protein coding gene	Chr1:122672925-122743906 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016264	protein coding gene	Chr1:136108220-136172604 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016832	protein coding gene	Chr1:120144061-120209096 (+)
PWK/PhJ	MGP_PWKPhJ_G0015528	protein coding gene	Chr1:114982391-115040612 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015316	protein coding gene	Chr1:119025146-119083764 (+)
WSB/EiJ	MGP_WSBEiJ_G0015804	protein coding gene	Chr1:120032136-120092326 (+)

Human Ortholog

TFCP2L1, transcription factor CP2 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TFCP2L1, transcription factor CP2 like 1
Synonyms

CRTR1, LBP-9, LBP9
Links

HGNC:17925

NCBI Gene ID: 29842

neXtProt AC: NX_Q9NZI6

UniProt: Q9NZI6
Chr Location

2q14.2; chr2:121216587-121285202 (-) GRCh38

MGI Vertebrate Homology

Tfcp2l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TFCP2L1
Gene Tree

Tfcp2l1

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

83
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

76
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Tfcp2l1
Incidental Mutations

APF
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for either a knock-out or a gene-trapped allele display a phenotype characterized by postnatal growth retardation, renal hypoplasia, impaired maturation of the ducts in the salivary gland and kidney, abnormal composition of saliva and urine, and postnatal lethality.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

72
cDNA Data

81
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TFCP2L1

Xenbase tfcp2l1

ZFIN tfcp2l1

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All Sequences

44
RefSeq

4
UniProt

1
CCDS

CCDS35691.1

Ensembl

ENSMUSG00000026380 (Evidence)
NCBI Gene

81879

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026380	Ensembl Gene Model \| MGI Sequence Detail	57224	C57BL/6J	± kb
transcript	ENSMUST00000027629	Ensembl \| MGI Sequence Detail	9269	Not Applicable
polypeptide	ENSMUSP00000027629	Ensembl \| MGI Sequence Detail	479	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030552 transcription factor CP2-like protein 1

(term hierarchy)
InterPro Domains

IPR007604 CP2 transcription factor

IPR041418 SAM domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR037598 TFCP2L1, SAM domain

IPR040167 Transcription factor CP2-like

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All nucleic 86

Genomic 2

cDNA 81

Primer pair 2

Other 1

Microarray probesets 6

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MGI:1916402, MGI:1921686, MGI:1932302, MGI:2138114

Summaries

All 72

Developmental Gene Expression 18

Gene Ontology 8

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:349916 Papinska JA, et al., Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjogren's Sicca Syndrome. Int J Mol Sci. 2024 May 30;25(11)

TSS for Tfcp2l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8376	Chr1:118555673-118555681 (+)	2 bp
Tssr8377	Chr1:118555716-118555744 (+)	55 bp
Tssr8378	Chr1:118555775-118555790 (+)	108 bp
Tssr8379	Chr1:118581481-118581485 (+)	25,808 bp
Tssr8380	Chr1:118603302-118603326 (+)	47,639 bp
Tssr8381	Chr1:118607154-118607166 (+)	51,485 bp
Tssr8382	Chr1:118611192-118611203 (+)	55,523 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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