Ccdc38 MGI Mouse Gene Detail - MGI:2444738 - coiled-coil domain containing 38

Symbol

Ccdc38
Name

coiled-coil domain containing 38
Synonyms

4933417K05Rik

Feature Type

protein coding gene
IDs

MGI:2444738
NCBI Gene: 237465
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:93376494-93420189 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 48.55 cM
Mapping Data

1 experiment

SNPs within 2kb

1484 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444738	protein coding gene	Chr10:93376451-93420189 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017653	protein coding gene	Chr10:94961814-95008766 (+)
A/J	MGP_AJ_G0017632	protein coding gene	Chr10:91657811-91703451 (+)
AKR/J	MGP_AKRJ_G0017590	protein coding gene	Chr10:94279874-94324287 (+)
BALB/cJ	MGP_BALBcJ_G0017595	protein coding gene	Chr10:91926030-91970262 (+)
C3H/HeJ	MGP_C3HHeJ_G0017418	protein coding gene	Chr10:94284044-94328764 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018052	protein coding gene	Chr10:98084778-98138624 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015734	protein coding gene	Chr10:87252837-87297906 (+)
CAST/EiJ	MGP_CASTEiJ_G0016983	protein coding gene	Chr10:94251658-94298286 (+)
CBA/J	MGP_CBAJ_G0017387	protein coding gene	Chr10:102160937-102207502 (+)
DBA/2J	MGP_DBA2J_G0017493	protein coding gene	Chr10:90754083-90801045 (+)
FVB/NJ	MGP_FVBNJ_G0017485	protein coding gene	Chr10:89964077-90008831 (+)
LP/J	MGP_LPJ_G0017567	protein coding gene	Chr10:95586773-95629494 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017516	protein coding gene	Chr10:103466778-103512692 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018089	protein coding gene	Chr10:94169360-94217636 (+)
PWK/PhJ	MGP_PWKPhJ_G0016764	protein coding gene	Chr10:90833897-90879930 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016552	protein coding gene	Chr10:92968080-93016673 (+)
WSB/EiJ	MGP_WSBEiJ_G0017042	protein coding gene	Chr10:94143388-94190723 (+)

Human Ortholog

CCDC38, coiled-coil domain containing 38

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC38, coiled-coil domain containing 38
Links

HGNC:26843

NCBI Gene ID: 120935

neXtProt AC: NX_Q502W7

UniProt: Q502W7
Chr Location

12q23.1; chr12:95867048-95943233 (-) GRCh38

MGI Vertebrate Homology

Ccdc38 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CCDC38
Gene Tree

Ccdc38

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Phenotype Summary

25 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

8
Targeted

2
Transposon induced

1
Genomic Mutations

2 involving Ccdc38
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit male sterility associated with oligospermia and asthenospermia, impaired spermiogenesis, elongated and ectopic manchettes, and teratospermia with multiple morphological abnormalities of the sperm flagella.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc38

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All Sequences

42
RefSeq

6
UniProt

1
CCDS

CCDS24127.1, CCDS88074.1

Ensembl

ENSMUSG00000036168 (Evidence)
NCBI Gene

237465

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036168	Ensembl Gene Model \| MGI Sequence Detail	43696	C57BL/6J	± kb
transcript	ENSMUST00000092215	Ensembl \| MGI Sequence Detail	3656	Not Applicable
polypeptide	ENSMUSP00000089860	Ensembl \| MGI Sequence Detail	563	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029329 coiled-coil domain-containing protein 38

(term hierarchy)
InterPro Domains

IPR051147 Cilia- and flagella-associated domain-containing protein

IPR025252 Domain of unknown function DUF4200

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All nucleic 12

cDNA 12

Microarray probesets 6

Summaries

All 34

Gene Ontology 8

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345053 Wang Y, et al., Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. J Genet Genomics. 2023 Sep 13;

TSS for Ccdc38:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95269	Chr10:93376467-93376476 (+)	-22 bp
Tssr95270	Chr10:93376488-93376515 (+)	8 bp
Tssr95271	Chr10:93387691-93387692 (+)	11,198 bp
Tssr95272	Chr10:93390724-93390728 (+)	14,232 bp
Tssr95273	Chr10:93390740-93390748 (+)	14,250 bp
Tssr95274	Chr10:93414433-93414448 (+)	37,947 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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