Mavs MGI Mouse Gene Detail - MGI:2444773 - mitochondrial antiviral signaling protein

Symbol

Mavs
Name

mitochondrial antiviral signaling protein
Synonyms

D430028G21Rik, IPS-1

Feature Type

protein coding gene
IDs

MGI:2444773
NCBI Gene: 228607
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:131075983-131089945 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.30 cM
Mapping Data

2 experiments

SNPs within 2kb

361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444773	protein coding gene	Chr2:131075445-131089945 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026528	protein coding gene	Chr2:134750090-134763990 (+)
A/J	MGP_AJ_G0026492	protein coding gene	Chr2:129281041-129294971 (+)
AKR/J	MGP_AKRJ_G0026467	protein coding gene	Chr2:133013180-133027114 (+)
BALB/cJ	MGP_BALBcJ_G0026504	protein coding gene	Chr2:129667302-129682969 (+)
C3H/HeJ	MGP_C3HHeJ_G0026247	protein coding gene	Chr2:133451878-133465766 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026949	protein coding gene	Chr2:138886815-138900723 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024326	protein coding gene	Chr2:124022444-124036455 (+)
CAST/EiJ	MGP_CASTEiJ_G0025708	protein coding gene	Chr2:133733257-133747030 (+)
CBA/J	MGP_CBAJ_G0026227	protein coding gene	Chr2:144059874-144073777 (+)
DBA/2J	MGP_DBA2J_G0026361	protein coding gene	Chr2:128670596-128684472 (+)
FVB/NJ	MGP_FVBNJ_G0026325	protein coding gene	Chr2:127300591-127314579 (+)
LP/J	MGP_LPJ_G0026466	protein coding gene	Chr2:134981071-134994929 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026345	protein coding gene	Chr2:147879412-147894395 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027004	protein coding gene	Chr2:132979878-132993765 (+)
PWK/PhJ	MGP_PWKPhJ_G0025444	protein coding gene	Chr2:128245594-128259820 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025246	protein coding gene	Chr2:132127811-132143693 (+)
WSB/EiJ	MGP_WSBEiJ_G0025782	protein coding gene	Chr2:133893953-133907888 (+)

Human Ortholog

MAVS, mitochondrial antiviral signaling protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAVS, mitochondrial antiviral signaling protein
Synonyms

CARDIF, IPS-1, IPS1, VISA
Links

HGNC:29233

NCBI Gene ID: 57506

neXtProt AC: NX_Q7Z434

UniProt: Q7Z434
Chr Location

20p13; chr20:3846799-3876123 (+) GRCh38

MGI Vertebrate Homology

Mavs stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAVS
Gene Tree

Mavs

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Phenotype Summary

41 phenotypes from 5 alleles in 8 genetic backgrounds
29 phenotypes from multigenic genotypes
245 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

6
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Mavs
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous and heterozygous mice for mutations display defective innate immunity in response to viral infections.

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All GO Annotations

72
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

76
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN mavs

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All Sequences

65
RefSeq

12
UniProt

3
CCDS

CCDS16760.1

Ensembl

ENSMUSG00000037523 (Evidence)
NCBI Gene

228607

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037523	Ensembl Gene Model \| MGI Sequence Detail	13963	C57BL/6J	± kb
transcript	ENSMUST00000041362	Ensembl \| MGI Sequence Detail	2867	Not Applicable
polypeptide	ENSMUSP00000038339	Ensembl \| MGI Sequence Detail	503	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010210 mitochondrial antiviral-signaling protein

(term hierarchy)
PDB

4GHU
InterPro Domains

IPR031964 Caspase recruitment domain

IPR011029 Death-like domain superfamily

IPR042144 IPS1, CARD domain

IPR052787 Mitochondrial antiviral-signaling domain-containing protein
GlyGen

Q8VCF0 16 sites, 1 O-linked glycan (16 sites)

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All nucleic 76

cDNA 76

Microarray probesets 4

Summaries

All 312

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 245
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:350802 Li T, et al., MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation. Int Immunopharmacol. 2024 Mar 8;131:111819

TSS for Mavs:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20257	Chr2:131074671-131074689 (+)	-1,303 bp
Tssr20258	Chr2:131075963-131076056 (+)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24