Bod1l MGI Mouse Gene Detail - MGI:2444804 - biorientation of chromosomes in cell division 1-like

Symbol

Bod1l
Name

biorientation of chromosomes in cell division 1-like
Synonyms

A230054D04Rik, mKIAA1327

Feature Type

protein coding gene
IDs

MGI:2444804
NCBI Gene: 665775
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:41944881-42001658 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 22.58 cM
Mapping Data

2 experiments

SNPs within 2kb

1406 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444804	protein coding gene	Chr5:41944881-42001695 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029519	protein coding gene	Chr5:40373085-40434475 (-)
A/J	MGP_AJ_G0029485	protein coding gene	Chr5:39018572-39075232 (-)
AKR/J	MGP_AKRJ_G0029435	protein coding gene	Chr5:40412303-40469441 (-)
BALB/cJ	MGP_BALBcJ_G0029496	protein coding gene	Chr5:39457393-39514299 (-)
C3H/HeJ	MGP_C3HHeJ_G0029219	protein coding gene	Chr5:40406306-40466343 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029950	protein coding gene	Chr5:42405932-42467307 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027188	protein coding gene	Chr5:36405802-36460950 (-)
CAST/EiJ	MGP_CASTEiJ_G0028627	protein coding gene	Chr5:39517583-39576351 (-)
CBA/J	MGP_CBAJ_G0029186	protein coding gene	Chr5:43463168-43526491 (-)
DBA/2J	MGP_DBA2J_G0029333	protein coding gene	Chr5:39091041-39157415 (-)
FVB/NJ	MGP_FVBNJ_G0029292	protein coding gene	Chr5:38530942-38587907 (-)
LP/J	MGP_LPJ_G0029419	protein coding gene	Chr5:40812963-40872549 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029322	protein coding gene	Chr5:44296776-44357306 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029983	protein coding gene	Chr5:39896528-39958458 (-)
PWK/PhJ	MGP_PWKPhJ_G0028351	protein coding gene	Chr5:38262248-38320865 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028185	protein coding gene	Chr5:39403834-39465427 (-)
WSB/EiJ	MGP_WSBEiJ_G0028708	protein coding gene	Chr5:39968207-40026423 (-)

Human Ortholog

BOD1L1, biorientation of chromosomes in cell division 1 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BOD1L1, biorientation of chromosomes in cell division 1 like 1
Synonyms

BOD1L, FAM44A
Links

HGNC:31792

NCBI Gene ID: 259282

neXtProt AC: NX_Q8NFC6

UniProt: Q8NFC6
Chr Location

4p15.33; chr4:13568738-13627725 (-) GRCh38

MGI Vertebrate Homology

Bod1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BOD1L1
Gene Tree

Bod1l

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

6 involving Bod1l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

111 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

mice homozygous for a conditional allele activated in B cells exhibit reduced Ig serum levels and class switch recombination.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

17
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bod1l1

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All Sequences

74
RefSeq

25
UniProt

2
CCDS

CCDS39079.1, CCDS80273.1

Ensembl

ENSMUSG00000061755 (Evidence)
NCBI Gene

665775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061755	Ensembl Gene Model \| MGI Sequence Detail	56778	C57BL/6J	± kb
transcript	ENSMUST00000050556	Ensembl \| MGI Sequence Detail	10540	Not Applicable
polypeptide	ENSMUSP00000058618	Ensembl \| MGI Sequence Detail	3032	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030831 biorientation of chromosomes in cell division protein 1-like 1

(term hierarchy)
InterPro Domains

IPR026955 Biorientation of chromosomes in cell division protein 1

IPR043244 Biorientation of chromosomes in cell division protein 1-like 1
GlyGen

E9Q6J5 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 7

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MGI:2140798, MGI:2140997

Summaries

All 49

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 23
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:337726 Bayley R, et al., H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Mol Cell. 2022 May 19;82(10):1924-1939.e10

TSS for Bod1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50855	Chr5:42001575-42001672 (-)	34 bp
Tssr50854	Chr5:41989908-41989930 (-)	11,739 bp
Tssr50853	Chr5:41986180-41986193 (-)	15,471 bp
Tssr50852	Chr5:41978781-41978804 (-)	22,865 bp
Tssr50851	Chr5:41976726-41976734 (-)	24,928 bp
Tssr50850	Chr5:41976350-41976367 (-)	25,299 bp
Tssr50849	Chr5:41967422-41967448 (-)	34,223 bp
Tssr50848	Chr5:41964538-41964570 (-)	37,104 bp
Tssr50847	Chr5:41957261-41957281 (-)	44,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24