Slc41a1 MGI Mouse Gene Detail - MGI:2444823 - solute carrier family 41, member 1

Symbol

Slc41a1
Name

solute carrier family 41, member 1
Synonyms

B230315F01Rik

Feature Type

protein coding gene
IDs

MGI:2444823
NCBI Gene: 98396
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:131755236-131776601 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.20 cM
Mapping Data

2 experiments

SNPs within 2kb

654 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444823	protein coding gene	Chr1:131755231-131776603 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016460	protein coding gene	Chr1:135260030-135281397 (+)
A/J	MGP_AJ_G0016443	protein coding gene	Chr1:130266683-130288006 (+)
AKR/J	MGP_AKRJ_G0016408	protein coding gene	Chr1:134088412-134110152 (+)
BALB/cJ	MGP_BALBcJ_G0016403	protein coding gene	Chr1:130585921-130607280 (+)
C3H/HeJ	MGP_C3HHeJ_G0016229	protein coding gene	Chr1:134234232-134255745 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016864	protein coding gene	Chr1:140292699-140314371 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0015809	protein coding gene	Chr1:133227380-133250743 (+)
CBA/J	MGP_CBAJ_G0016201	protein coding gene	Chr1:145083856-145105215 (+)
DBA/2J	MGP_DBA2J_G0016308	protein coding gene	Chr1:129228079-129249415 (+)
FVB/NJ	MGP_FVBNJ_G0016307	protein coding gene	Chr1:127854647-127875988 (+)
LP/J	MGP_LPJ_G0016379	protein coding gene	Chr1:136584947-136606386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016332	protein coding gene	Chr1:150859184-150880851 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016900	protein coding gene	Chr1:133849578-133870858 (+)
PWK/PhJ	MGP_PWKPhJ_G0015595	protein coding gene	Chr1:128185092-128208513 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015382	protein coding gene	Chr1:132792698-132813930 (+)
WSB/EiJ	MGP_WSBEiJ_G0015871	protein coding gene	Chr1:133835221-133856541 (+)

Human Ortholog

SLC41A1, solute carrier family 41 member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC41A1, solute carrier family 41 member 1
Synonyms

MgtE, NPHPL2
Links

HGNC:19429

NCBI Gene ID: 254428

neXtProt AC: NX_Q8IVJ1

UniProt: Q8IVJ1
Chr Location

1q32.1; chr1:205789094-205813748 (-) GRCh38

MGI Vertebrate Homology

Slc41a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC41A1
Gene Tree

Slc41a1

Diseases

1 with human SLC41A1 associations

				Human Disease	Mouse Models
				nephronophthisis IDs nephronophthisis DOID:12712 ICD10CM:Q61.5 ICD9CM_2006:753.16 NCI:C123200 OMIM:PS256100 ORDO:655 UMLS_CUI:C0687120

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

3 involving Slc41a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Homozygous null mice exhibit partial rescue of the negative effects of magnesium starvation on Krebs cycle enzyme activity in cardiac mitochondria and increased electron transport chain complex I, III, IV, and V activities but decreased complex II activity irrespective of the type of magnesium diet.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

967
Tissues

132
cDNA Data

69
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc41a1

ZFIN slc41a1

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS15275.1

Ensembl

ENSMUSG00000013275 (Evidence)
NCBI Gene

98396

			Length	Strain/Species	Flank
genomic	98396	NCBI Gene Model \| MGI Sequence Detail	21366	C57BL/6J	± kb
transcript	NM_173865	RefSeq \| MGI Sequence Detail	4675	C57BL/6
polypeptide	Q8BJA2	UniProt \| EBI \| MGI Sequence Detail	512	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015139 solute carrier family 41 member 1

(term hierarchy)
InterPro Domains

IPR045349 SLC41A divalent cation transporter

IPR036739 SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily

IPR006667 SLC41A/MgtE, integral membrane domain

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All nucleic 71

cDNA 69

Primer pair 2

Microarray probesets 3

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MGI:2138291

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc41a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8669	Chr1:131755258-131755275 (+)	31 bp
Tssr8670	Chr1:131755740-131755757 (+)	513 bp
Tssr8671	Chr1:131755770-131755787 (+)	543 bp
Tssr8672	Chr1:131755795-131755804 (+)	564 bp
Tssr8673	Chr1:131755811-131755817 (+)	578 bp
Tssr8674	Chr1:131756053-131756079 (+)	830 bp
Tssr8675	Chr1:131756081-131756101 (+)	855 bp
Tssr8676	Chr1:131756724-131756730 (+)	1,491 bp
Tssr8677	Chr1:131766534-131766547 (+)	11,305 bp
Tssr8678	Chr1:131771729-131771744 (+)	16,501 bp
Tssr8679	Chr1:131774466-131774493 (+)	19,244 bp
Tssr8680	Chr1:131775300-131775317 (+)	20,073 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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