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Ripor2 Gene Detail
Summary
  • Symbol
    Ripor2
  • Name
    RHO family interacting cell polarization regulator 2
  • Synonyms
    1700108N18Rik, 6330500D04Rik, E430013J17Rik, Fam65b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444879
    NCBI Gene: 193385
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:24685513-24917789 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 10.50 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444879
 protein coding gene Chr13:24685508-24917799 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020378
 protein coding gene Chr13:22061472-22224500 (+)
A/J MGP_AJ_G0020327
 protein coding gene Chr13:21647174-21804008 (+)
AKR/J MGP_AKRJ_G0020307
 protein coding gene Chr13:21900300-22054134 (+)
BALB/cJ MGP_BALBcJ_G0020325
 protein coding gene Chr13:21642810-21801575 (+)
C3H/HeJ MGP_C3HHeJ_G0020129
 protein coding gene Chr13:22009964-22134407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020762
 protein coding gene Chr13:22854577-23020321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018350
 protein coding gene Chr13:20425470-20543332 (+)
CAST/EiJ MGP_CASTEiJ_G0019646
 protein coding gene Chr13:21676708-21852243 (+)
CBA/J MGP_CBAJ_G0020083
 protein coding gene Chr13:23755206-23892007 (+)
DBA/2J MGP_DBA2J_G0020209
 protein coding gene Chr13:21163556-21322895 (+)
FVB/NJ MGP_FVBNJ_G0020193
 protein coding gene Chr13:20804752-20958717 (+)
LP/J MGP_LPJ_G0020282
 protein coding gene Chr13:22369808-22528953 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020220
 protein coding gene Chr13:23988714-24149511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020804
 protein coding gene Chr13:21754187-21916500 (+)
PWK/PhJ MGP_PWKPhJ_G0019400
 protein coding gene Chr13:21187944-21341757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019216
 protein coding gene Chr13:20606800-20733874 (+)
WSB/EiJ MGP_WSBEiJ_G0019706
 protein coding gene Chr13:21910566-22069687 (+)



Homology
more
  • Human Ortholog
    RIPOR2, RHO family interacting cell polarization regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIPOR2, RHO family interacting cell polarization regulator 2
  • Synonyms
    C6orf32, DFNA21, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48
  • Links
    NCBI Gene ID: 9750
    neXtProt AC: NX_Q9Y4F9
    UniProt: Q9Y4F9

  • Chr Location
    6p22.3; chr6:24804282-25042170 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RIPOR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice are deaf. The gene product is expressed in the basal region of cochlear hair cell stereocillia, which are disorganized and malformed in null mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    16
  • cDNA Data
    77
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 193385 NCBI Gene Model | MGI Sequence Detail 232277 C57BL/6J ±  kb
transcript NM_001402913 RefSeq | MGI Sequence Detail 5733 C57BL/6  
polypeptide Q80U16 UniProt | EBI | MGI Sequence Detail 1078 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 78
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1923872, MGI:2145192, MGI:5897558
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:329331 Li J, et al., RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss. Dev Cell. 2022 Sep 26;57(18):2204-2220.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory