Abra MGI Mouse Gene Detail - MGI:2444891 - actin-binding Rho activating protein

Symbol

Abra
Name

actin-binding Rho activating protein
Synonyms

C130068O12Rik, STARS

Feature Type

protein coding gene
IDs

MGI:2444891
NCBI Gene: 223513
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:41728689-41733116 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 16.42 cM
Mapping Data

1 experiment

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444891	protein coding gene	Chr15:41727472-41733116 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021822	protein coding gene	Chr15:40417456-40421865 (-)
A/J	MGP_AJ_G0021782	protein coding gene	Chr15:38846834-38851242 (-)
AKR/J	MGP_AKRJ_G0021763	protein coding gene	Chr15:40035943-40040352 (-)
BALB/cJ	MGP_BALBcJ_G0021789	protein coding gene	Chr15:38935460-38939887 (-)
C3H/HeJ	MGP_C3HHeJ_G0021563	protein coding gene	Chr15:39925544-39929953 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022228	protein coding gene	Chr15:41964345-41968772 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019765	protein coding gene	Chr15:36518891-36523247 (-)
CAST/EiJ	MGP_CASTEiJ_G0021080	protein coding gene	Chr15:40427639-40432050 (-)
CBA/J	MGP_CBAJ_G0021532	protein coding gene	Chr15:43420760-43425172 (-)
DBA/2J	MGP_DBA2J_G0021656	protein coding gene	Chr15:38691200-38695616 (-)
FVB/NJ	MGP_FVBNJ_G0021634	protein coding gene	Chr15:38020781-38025189 (-)
LP/J	MGP_LPJ_G0021726	protein coding gene	Chr15:40222503-40226912 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021658	protein coding gene	Chr15:46458592-46463012 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022251	protein coding gene	Chr15:40206502-40210908 (-)
PWK/PhJ	MGP_PWKPhJ_G0020825	protein coding gene	Chr15:38735961-38740375 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020662	protein coding gene	Chr15:39851161-39855554 (-)
WSB/EiJ	MGP_WSBEiJ_G0021135	protein coding gene	Chr15:40112893-40117305 (-)

Human Ortholog

ABRA, actin binding Rho activating protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABRA, actin binding Rho activating protein
Synonyms

STARS
Links

HGNC:30655

NCBI Gene ID: 137735

neXtProt AC: NX_Q8N0Z2

UniProt: Q8N0Z2
Chr Location

8q23.1; chr8:106759483-106770244 (-) GRCh38

MGI Vertebrate Homology

Abra stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ABRA
Gene Tree

Abra

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Endonuclease-mediated

1
Spontaneous

1
Targeted

1
Genomic Mutations

3 involving Abra
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

33
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abra

ZFIN abraa, abrab

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS27449.1

Ensembl

ENSMUSG00000042895 (Evidence)
NCBI Gene

223513

			Length	Strain/Species	Flank
genomic	223513	NCBI Gene Model \| MGI Sequence Detail	4428	C57BL/6J	± kb
transcript	NM_175456	RefSeq \| MGI Sequence Detail	1762	C57BL/6
polypeptide	Q8BUZ1	UniProt \| EBI \| MGI Sequence Detail	375	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003590 actin-binding Rho-activating protein

(term hierarchy)
InterPro Domains

IPR026111 Actin-binding Rho-activating protein

IPR027817 Costars domain

IPR038095 Costars domain superfamily

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:278242 Xia M, et al., HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13):dev177477

TSS for Abra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134159	Chr15:41733099-41733123 (-)	5 bp
Tssr134158	Chr15:41733088-41733097 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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