Apol8 MGI Mouse Gene Detail - MGI:2444921

Symbol

Apol8
Name

apolipoprotein L 8
Synonyms

9830006J20Rik, Apol2

Feature Type

protein coding gene
IDs

MGI:2444921
NCBI Gene: 239552
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:77631998-77641203 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.79 cM
Mapping Data

1 experiment

SNPs within 2kb

415 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444921	protein coding gene	Chr15:77629309-77641306 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022030	protein coding gene	Chr15:77873902-77881324 (-)
A/J	MGP_AJ_G0021990	protein coding gene	Chr15:75181686-75189104 (-)
AKR/J	MGP_AKRJ_G0021967	protein coding gene	Chr15:77259866-77267296 (-)
BALB/cJ	MGP_BALBcJ_G0021998	protein coding gene	Chr15:75193063-75200487 (-)
C3H/HeJ	MGP_C3HHeJ_G0021769	protein coding gene	Chr15:77339434-77346854 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022440	protein coding gene	Chr15:80949181-80956607 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019969	protein coding gene	Chr15:71756271-71764636 (-)
CAST/EiJ	MGP_CASTEiJ_G0021289	protein coding gene	Chr15:77918325-77925752 (-)
CBA/J	MGP_CBAJ_G0021734	protein coding gene	Chr15:83441012-83448430 (-)
DBA/2J	MGP_DBA2J_G0021862	protein coding gene	Chr15:74676803-74684197 (-)
FVB/NJ	MGP_FVBNJ_G0021841	protein coding gene	Chr15:73669273-73676683 (-)
LP/J	MGP_LPJ_G0021931	protein coding gene	Chr15:78063946-78071406 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021861	protein coding gene	Chr15:88650796-88658975 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022454	protein coding gene	Chr15:77336743-77349667 (-)
PWK/PhJ	MGP_PWKPhJ_G0021031	protein coding gene	Chr15:74657607-74665079 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020867	protein coding gene	Chr15:77112343-77120854 (-)
WSB/EiJ	MGP_WSBEiJ_G0021342	protein coding gene	Chr15:77655855-77669893 (-)

Human Ortholog

APOL1, apolipoprotein L1

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOL1, apolipoprotein L1
Synonyms

APO-L, APOL, APOL-I, FSGS4
Links

HGNC:618

NCBI Gene ID: 8542

neXtProt AC: NX_O14791

UniProt: O14791
Chr Location

22q12.3; chr22:36253071-36267530 (+) GRCh38

Human Ortholog

APOL2, apolipoprotein L2
Synonyms

APOL3, APOL-II
Links

HGNC:619

NCBI Gene ID: 23780

neXtProt AC: NX_Q9BQE5

UniProt: Q9BQE5
Chr Location

22q12.3; chr22:36226209-36239954 (-) GRCh38

Human Ortholog

APOL3, apolipoprotein L3
Synonyms

apoL-III, APOLIII, CG12_1, CG121
Links

HGNC:14868

NCBI Gene ID: 80833

neXtProt AC: NX_O95236

UniProt: O95236
Chr Location

22q12.3; chr22:36140323-36166177 (-) GRCh38

Human Ortholog

APOL4, apolipoprotein L4
Synonyms

APOL-IV, APOLIV
Links

HGNC:14867

NCBI Gene ID: 80832

neXtProt AC: NX_Q9BPW4

UniProt: Q9BPW4
Chr Location

22q12.3; chr22:36189124-36204840 (-) GRCh38

MGI Vertebrate Homology

Apol8 stringent orthology
4 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: APOL1, APOL2, APOL3, APOL4
Gene Tree

Apol8

Diseases

1 with human APOL2,APOL4 associations

				Human Disease	Mouse Models
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

27 phenotype references

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

2
Targeted

2
Genomic Mutations

4 involving Apol8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

1
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

27
UniProt

4
CCDS

CCDS56989.1

Ensembl

ENSMUSG00000056656 (Evidence)
NCBI Gene

239552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056656	Ensembl Gene Model \| MGI Sequence Detail	9206	C57BL/6J	± kb
transcript	ENSMUST00000070911	Ensembl \| MGI Sequence Detail	2801	Not Applicable
polypeptide	ENSMUSP00000064237	Ensembl \| MGI Sequence Detail	339	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR008405 Apolipoprotein L

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All nucleic 7

cDNA 7

Microarray probesets 2

Summaries

All 46

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Apol8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135106	Chr15:77639466-77639481 (-)	1,729 bp
Tssr135105	Chr15:77639418-77639465 (-)	1,761 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24