Tmco3 MGI Mouse Gene Detail - MGI:2444946 - transmembrane and coiled-coil domains 3

Symbol

Tmco3
Name

transmembrane and coiled-coil domains 3
Synonyms

B230339H12Rik

Feature Type

protein coding gene
IDs

MGI:2444946
NCBI Gene: 234076
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:13338190-13372924 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

2 experiments

SNPs within 2kb

1121 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444946	protein coding gene	Chr8:13333214-13372924 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033377	protein coding gene	Chr8:10627615-10666126 (+)
A/J	MGP_AJ_G0033357	protein coding gene	Chr8:10241087-10280925 (+)
AKR/J	MGP_AKRJ_G0033288	protein coding gene	Chr8:10523225-10559929 (+)
BALB/cJ	MGP_BALBcJ_G0033358	protein coding gene	Chr8:10374909-10411449 (+)
C3H/HeJ	MGP_C3HHeJ_G0033071	protein coding gene	Chr8:10730793-10772737 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033870	protein coding gene	Chr8:11000999-11035460 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030839	protein coding gene	Chr8:9746343-9781303 (+)
CAST/EiJ	MGP_CASTEiJ_G0032393	protein coding gene	Chr8:10490999-10533056 (+)
CBA/J	MGP_CBAJ_G0033044	protein coding gene	Chr8:11458645-11502883 (+)
DBA/2J	MGP_DBA2J_G0033197	protein coding gene	Chr8:10190369-10227356 (+)
FVB/NJ	MGP_FVBNJ_G0033146	protein coding gene	Chr8:10207354-10242666 (+)
LP/J	MGP_LPJ_G0033291	protein coding gene	Chr8:10534118-10574706 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033180	protein coding gene	Chr8:11689963-11727196 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033887	protein coding gene	Chr8:10580171-10621222 (+)
PWK/PhJ	MGP_PWKPhJ_G0032106	protein coding gene	Chr8:10243002-10280029 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031948	protein coding gene	Chr8:10472296-10508804 (+)
WSB/EiJ	MGP_WSBEiJ_G0032509	protein coding gene	Chr8:10616834-10654604 (+)

Human Ortholog

TMCO3, transmembrane and coiled-coil domains 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMCO3, transmembrane and coiled-coil domains 3
Synonyms

C13orf11
Links

HGNC:20329

NCBI Gene ID: 55002

neXtProt AC: NX_Q6UWJ1

UniProt: Q6UWJ1
Chr Location

13q34; chr13:113491021-113554590 (+) GRCh38

MGI Vertebrate Homology

Tmco3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMCO3
Gene Tree

Tmco3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

31
cDNA Data

47
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmco3

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All Sequences

60
RefSeq

10
UniProt

2
CCDS

CCDS40231.1

Ensembl

ENSMUSG00000038497 (Evidence)
NCBI Gene

234076

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038497	Ensembl Gene Model \| MGI Sequence Detail	34735	C57BL/6J	± kb
transcript	ENSMUST00000045229	Ensembl \| MGI Sequence Detail	4335	Not Applicable
polypeptide	ENSMUSP00000040347	Ensembl \| MGI Sequence Detail	678	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016400 transmembrane and coiled-coil domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR045158 K(+) efflux antiporter 4/5/6-like

IPR038770 Sodium/solute symporter superfamily
GlyGen

Q8BH01 4 sites, 1 O-linked glycan (1 site)

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All nucleic 47

cDNA 47

Microarray probesets 4

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MGI:2142882

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmco3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76388	Chr8:13337887-13337929 (+)	-282 bp
Tssr76389	Chr8:13338173-13338220 (+)	7 bp
Tssr76390	Chr8:13338237-13338263 (+)	60 bp
Tssr76391	Chr8:13338283-13338290 (+)	97 bp
Tssr76392	Chr8:13342689-13342727 (+)	4,518 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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