Mical2 MGI Mouse Gene Detail - MGI:2444947 - microtubule associated monooxygenase, calponin and LIM domain containing 2

Symbol

Mical2
Name

microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms

4921517J23Rik, 5330438E18Rik, Ebitein1, Micalcl

Feature Type

protein coding gene
IDs

MGI:2444947
NCBI Gene: 320878
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:111825063-112012313 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 58.75 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

5542 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444947	protein coding gene	Chr7:111825032-112012313 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032868	protein coding gene	Chr7:115786194-115922293 (+)
A/J	MGP_AJ_G0032851	protein coding gene	Chr7:112908020-113039029 (+)
AKR/J	MGP_AKRJ_G0032783	protein coding gene	Chr7:115746715-115883916 (+)
BALB/cJ	MGP_BALBcJ_G0032856	protein coding gene	Chr7:112597045-112731991 (+)
C3H/HeJ	MGP_C3HHeJ_G0032566	protein coding gene	Chr7:115738624-115875614 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033362	protein coding gene	Chr7:120528154-120664722 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030334	protein coding gene	Chr7:114506102-114633659 (+)
CAST/EiJ	MGP_CASTEiJ_G0031894	protein coding gene	Chr7:107351962-107487756 (+)
CBA/J	MGP_CBAJ_G0032539	protein coding gene	Chr7:124490754-124635184 (+)
DBA/2J	MGP_DBA2J_G0032691	protein coding gene	Chr7:110991088-111121585 (+)
FVB/NJ	MGP_FVBNJ_G0032644	protein coding gene	Chr7:110838584-110971850 (+)
LP/J	MGP_LPJ_G0032785	protein coding gene	Chr7:117297525-117431563 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032676	protein coding gene	Chr7:126107655-126241116 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033382	protein coding gene	Chr7:114751163-114885688 (+)
PWK/PhJ	MGP_PWKPhJ_G0031601	protein coding gene	Chr7:103829452-103961474 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031449	protein coding gene	Chr7:101496695-101629376 (+)
WSB/EiJ	MGP_WSBEiJ_G0032007	protein coding gene	Chr7:115608927-115741989 (+)

Human Ortholog

MICAL2, microtubule associated monooxygenase, calponin and LIM domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MICAL2, microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms

Ebitein1, MICAL-2, MICAL2PV1, MICAL2PV2, mical-cL, MICALCL
Links

HGNC:24693

NCBI Gene ID: 9645

neXtProt AC: NX_O94851

UniProt: O94851
Chr Location

11p15.3; chr11:12094008-12362140 (+) GRCh38

MGI Vertebrate Homology

Mical2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MICAL2
Gene Tree

Mical2

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Mical2
Incidental Mutations

Mutagenetix , Mutagenetix , APF , APF , CvDC , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

4
cDNA Data

26
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mical2

ZFIN mical2a, mical2b

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All Sequences

89
RefSeq

23
UniProt

5
CCDS

CCDS21753.1, CCDS52364.1, CCDS57581.1

Ensembl

ENSMUSG00000038244 (Evidence)
NCBI Gene

320878

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038244	Ensembl Gene Model \| MGI Sequence Detail	187251	C57BL/6J	± kb
transcript	ENSMUST00000037991	Ensembl \| MGI Sequence Detail	3352	Not Applicable
polypeptide	ENSMUSP00000047639	Ensembl \| MGI Sequence Detail	1102	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010400 [F-actin]-monooxygenase MICAL2

(term hierarchy)
EC

1.14.13.225
InterPro Domains

IPR022735 bMERB domain

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR050540 F-actin Monooxygenase Mical

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR001781 Zinc finger, LIM-type

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All nucleic 27

cDNA 26

Primer pair 1

Microarray probesets 5

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MGI:1918127

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 10
Earliest

J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
Latest

J:333149 Zhao T, et al., Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators. Biol Reprod. 2022 Jul 25;107(1):135-147

TSS for Mical2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68556	Chr7:111825044-111825055 (+)	-13 bp
Tssr68557	Chr7:111825064-111825107 (+)	23 bp
Tssr68558	Chr7:111825958-111825996 (+)	914 bp
Tssr68559	Chr7:111837709-111837720 (+)	12,652 bp
Tssr68560	Chr7:111837734-111837745 (+)	12,677 bp
Tssr68561	Chr7:111841070-111841081 (+)	16,013 bp
Tssr68562	Chr7:111882854-111882859 (+)	57,794 bp
Tssr68563	Chr7:111909807-111909811 (+)	84,746 bp
Tssr68564	Chr7:111935800-111935813 (+)	110,744 bp
Tssr68565	Chr7:111941606-111941610 (+)	116,545 bp
Tssr68566	Chr7:111953766-111953779 (+)	128,710 bp
Tssr68567	Chr7:111954030-111954047 (+)	128,976 bp
Tssr68568	Chr7:111960840-111960852 (+)	135,783 bp
Tssr68569	Chr7:111974046-111974071 (+)	148,996 bp
Tssr68570	Chr7:111974420-111974466 (+)	149,380 bp
Tssr68571	Chr7:111990402-111990417 (+)	165,347 bp
Tssr68572	Chr7:111990456-111990476 (+)	165,403 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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