Ark2n MGI Mouse Gene Detail - MGI:2444951 - arkadia (RNF111) N-terminal like PKA signaling regulator 2N

Symbol

Ark2n
Name

arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Synonyms

8030462N17Rik, Ark2N

Feature Type

protein coding gene
IDs

MGI:2444951
NCBI Gene: 212163
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:77719193-77802186 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 52.38 cM
Mapping Data

1 experiment

SNPs within 2kb

1500 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444951	protein coding gene	Chr18:77719184-77802190 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024577	protein coding gene	Chr18:78426600-78514910 (-)
A/J	MGP_AJ_G0024544	protein coding gene	Chr18:74981717-75088107 (-)
AKR/J	MGP_AKRJ_G0024515	protein coding gene	Chr18:77168147-77248877 (-)
BALB/cJ	MGP_BALBcJ_G0024543	protein coding gene	Chr18:75200829-75283868 (-)
C3H/HeJ	MGP_C3HHeJ_G0024312	protein coding gene	Chr18:77299806-77393042 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024990	protein coding gene	Chr18:80468785-80561417 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022420	protein coding gene	Chr18:73978219-74063977 (-)
CAST/EiJ	MGP_CASTEiJ_G0023784	protein coding gene	Chr18:77611166-77699855 (-)
CBA/J	MGP_CBAJ_G0024281	protein coding gene	Chr18:83337943-83433919 (-)
DBA/2J	MGP_DBA2J_G0024411	protein coding gene	Chr18:74553702-74635903 (-)
FVB/NJ	MGP_FVBNJ_G0024377	protein coding gene	Chr18:73916556-74000387 (-)
LP/J	MGP_LPJ_G0024495	protein coding gene	Chr18:78308676-78394971 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024407	protein coding gene	Chr18:84571538-84666840 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025038	protein coding gene	Chr18:77374820-77466440 (-)
PWK/PhJ	MGP_PWKPhJ_G0023529	protein coding gene	Chr18:74973946-75059388 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023333	protein coding gene	Chr18:77556395-77649734 (-)
WSB/EiJ	MGP_WSBEiJ_G0023848	protein coding gene	Chr18:77340790-77425686 (-)

Human Ortholog

ARK2N, arkadia (RNF111) N-terminal like PKA signaling regulator 2N

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARK2N, arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Synonyms

ARKL1, C18orf25, RNF111L1
Links

HGNC:28172

NCBI Gene ID: 147339

neXtProt AC: NX_Q96B23

UniProt: Q96B23
Chr Location

18q21.1; chr18:46173553-46266992 (+) GRCh38

MGI Vertebrate Homology

Ark2n stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARK2N
Gene Tree

Ark2n

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

124
Endonuclease-mediated

1
Gene trapped

122
Transposon induced

1
Genomic Mutations

1 involving Ark2n
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced skeletal muscle fiber size, exercise capacity, and muscle contractile function, and increased adiposity.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ark2n

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All Sequences

60
RefSeq

14
UniProt

7
CCDS

CCDS29355.1

Ensembl

ENSMUSG00000047466 (Evidence)
NCBI Gene

212163

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047466	Ensembl Gene Model \| MGI Sequence Detail	82994	C57BL/6J	± kb
transcript	ENSMUST00000074653	Ensembl \| MGI Sequence Detail	5125	Not Applicable
polypeptide	ENSMUSP00000074225	Ensembl \| MGI Sequence Detail	399	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000059992 protein ARK2N

(term hierarchy)
InterPro Domains

IPR029306 E3 ubiquitin-protein ligase Arkadia, N-terminal

IPR051073 ZNRF3/Arkadia E3 ubiquitin-protein ligases

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All nucleic 9

cDNA 9

Microarray probesets 1

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MGI:7447213

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:330717 Blazev R, et al., Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Cell Metab. 2022 Jul 19;

TSS for Ark2n:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153957	Chr18:77802146-77802201 (-)	12 bp
Tssr153956	Chr18:77801678-77801702 (-)	496 bp
Tssr153955	Chr18:77801616-77801673 (-)	541 bp
Tssr153954	Chr18:77777881-77777885 (-)	24,303 bp
Tssr153953	Chr18:77775157-77775161 (-)	27,027 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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