Phldb2 MGI Mouse Gene Detail - MGI:2444981 - pleckstrin homology like domain, family B, member 2

Symbol

Phldb2
Name

pleckstrin homology like domain, family B, member 2
Synonyms

C820004H04Rik, LL5b, LL5beta

Feature Type

protein coding gene
IDs

MGI:2444981
NCBI Gene: 208177
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr16:45566606-45773961 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.08 cM
Mapping Data

2 experiments

SNPs within 2kb

6330 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444981	protein coding gene	Chr16:45566593-45773961 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022859	protein coding gene	Chr16:44538399-44759813 (-)
A/J	MGP_AJ_G0022824	protein coding gene	Chr16:42545938-42760877 (-)
AKR/J	MGP_AKRJ_G0022796	protein coding gene	Chr16:43946640-44157703 (-)
BALB/cJ	MGP_BALBcJ_G0022825	protein coding gene	Chr16:42571358-42780359 (-)
C3H/HeJ	MGP_C3HHeJ_G0022589	protein coding gene	Chr16:44104978-44314396 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023272	protein coding gene	Chr16:45552225-45781350 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020786	protein coding gene	Chr16:42902088-43113698 (-)
CAST/EiJ	MGP_CASTEiJ_G0022114	protein coding gene	Chr16:44298933-44519351 (-)
CBA/J	MGP_CBAJ_G0022560	protein coding gene	Chr16:47464074-47690392 (-)
DBA/2J	MGP_DBA2J_G0022692	protein coding gene	Chr16:42285002-42492986 (-)
FVB/NJ	MGP_FVBNJ_G0022668	protein coding gene	Chr16:42196860-42405156 (-)
LP/J	MGP_LPJ_G0022760	protein coding gene	Chr16:44271953-44512443 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022686	protein coding gene	Chr16:46879334-47102245 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023287	protein coding gene	Chr16:43959187-44177646 (-)
PWK/PhJ	MGP_PWKPhJ_G0021854	protein coding gene	Chr16:42653553-42866235 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021685	protein coding gene	Chr16:43891958-44105796 (-)
WSB/EiJ	MGP_WSBEiJ_G0022159	protein coding gene	Chr16:44053648-44271014 (-)

Human Ortholog

PHLDB2, pleckstrin homology like domain family B member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHLDB2, pleckstrin homology like domain family B member 2
Synonyms

LL5b, LL5beta
Links

HGNC:29573

NCBI Gene ID: 90102

neXtProt AC: NX_Q86SQ0

UniProt: Q86SQ0
Chr Location

3q13.2; chr3:111732496-111976517 (+) GRCh38

MGI Vertebrate Homology

Phldb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PHLDB2
Gene Tree

Phldb2

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in neurons exhibit impaired LTP.

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All GO Annotations

37
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

73
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

109
RefSeq

50
UniProt

5
CCDS

CCDS28202.1, CCDS57031.1

Ensembl

ENSMUSG00000033149 (Evidence)
NCBI Gene

208177

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033149	Ensembl Gene Model \| MGI Sequence Detail	207356	C57BL/6J	± kb
transcript	ENSMUST00000076333	Ensembl \| MGI Sequence Detail	5347	Not Applicable
polypeptide	ENSMUSP00000075672	Ensembl \| MGI Sequence Detail	1302	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012666 pleckstrin homology-like domain family B member 2

(term hierarchy)
InterPro Domains

IPR037810 PHLDB1/2/3, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR052212 Pleckstrin homology-like domain-containing protein
GlyGen

Q8K1N2 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 73

cDNA 73

Microarray probesets 3

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MGI:2146603

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Phldb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141271	Chr16:45773928-45773966 (-)	14 bp
Tssr141270	Chr16:45773860-45773925 (-)	68 bp
Tssr141269	Chr16:45757840-45757851 (-)	16,115 bp
Tssr141268	Chr16:45746771-45746774 (-)	27,188 bp
Tssr141267	Chr16:45730824-45730866 (-)	43,116 bp
Tssr141266	Chr16:45707850-45707893 (-)	66,089 bp
Tssr141265	Chr16:45701075-45701076 (-)	72,885 bp
Tssr141264	Chr16:45665360-45665378 (-)	108,592 bp
Tssr141263	Chr16:45665333-45665350 (-)	108,619 bp
Tssr141262	Chr16:45664666-45664744 (-)	109,256 bp
Tssr141261	Chr16:45664591-45664599 (-)	109,366 bp
Tssr141260	Chr16:45663840-45663844 (-)	110,119 bp
Tssr141259	Chr16:45622143-45622153 (-)	151,813 bp
Tssr141258	Chr16:45620132-45620136 (-)	153,827 bp
Tssr141256	Chr16:45604854-45604867 (-)	169,100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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