Hmbox1 MGI Mouse Gene Detail - MGI:2445066

Symbol

Hmbox1
Name

homeobox containing 1
Synonyms

F830020C16Rik

Feature Type

protein coding gene
IDs

MGI:2445066
NCBI Gene: 219150
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:65049049-65187320 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.79 cM
Mapping Data

2 experiments

SNPs within 2kb

2777 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445066	protein coding gene	Chr14:65049049-65187354 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021474	protein coding gene	Chr14:59391302-59531626 (-)
A/J	MGP_AJ_G0021433	protein coding gene	Chr14:58028140-58166791 (-)
AKR/J	MGP_AKRJ_G0021409	protein coding gene	Chr14:60055262-60193132 (-)
BALB/cJ	MGP_BALBcJ_G0021439	protein coding gene	Chr14:57974745-58113228 (-)
C3H/HeJ	MGP_C3HHeJ_G0021216	protein coding gene	Chr14:59702604-59839524 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021878	protein coding gene	Chr14:62167616-62311275 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019418	protein coding gene	Chr14:55966374-56102839 (-)
CAST/EiJ	MGP_CASTEiJ_G0020733	protein coding gene	Chr14:56183331-56320156 (-)
CBA/J	MGP_CBAJ_G0021183	protein coding gene	Chr14:64034602-64176748 (-)
DBA/2J	MGP_DBA2J_G0021306	protein coding gene	Chr14:57687902-57826118 (-)
FVB/NJ	MGP_FVBNJ_G0021285	protein coding gene	Chr14:57086469-57221892 (-)
LP/J	MGP_LPJ_G0021381	protein coding gene	Chr14:60428012-60571319 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021314	protein coding gene	Chr14:63183408-63326919 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021901	protein coding gene	Chr14:59229222-59366682 (-)
PWK/PhJ	MGP_PWKPhJ_G0020477	protein coding gene	Chr14:54390431-54531807 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020310	protein coding gene	Chr14:55196939-55335808 (-)
WSB/EiJ	MGP_WSBEiJ_G0020786	protein coding gene	Chr14:59545112-59685544 (-)

Human Ortholog

HMBOX1, homeobox containing 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMBOX1, homeobox containing 1
Synonyms

HNF1LA, HOT1, PBHNF, TAH1
Links

HGNC:26137

NCBI Gene ID: 79618

neXtProt AC: NX_Q6NT76

UniProt: Q6NT76
Chr Location

8p21.1-p12; chr8:28890116-29064764 (+) GRCh38

MGI Vertebrate Homology

Hmbox1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HMBOX1
Gene Tree

Hmbox1

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

9
Targeted

3
Genomic Mutations

1 involving Hmbox1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit absence of TERT binding to chromatin as shown by subcellular fractionation analysis of mouse embryonic fibroblasts.

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All GO Annotations

36
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

48
cDNA Data

38
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HMBOX1

ZFIN hmbox1a

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All Sequences

93
RefSeq

34
UniProt

9
CCDS

CCDS36955.1, CCDS84149.1, CCDS84150.1

Ensembl

ENSMUSG00000021972 (Evidence)
NCBI Gene

219150

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021972	Ensembl Gene Model \| MGI Sequence Detail	138272	C57BL/6J	± kb
transcript	ENSMUST00000177326	Ensembl \| MGI Sequence Detail	1729	Not Applicable
polypeptide	ENSMUSP00000135372	Ensembl \| MGI Sequence Detail	445	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008622 homeobox-containing protein 1

(term hierarchy)
InterPro Domains

IPR001387 Cro/C1-type helix-turn-helix domain

IPR006899 Hepatocyte nuclear factor 1, N-terminal

IPR044866 HNF-1, dimerization domain

IPR044869 HNF-1, POU-specific (POUs) atypical domain

IPR040363 Homeobox-containing protein 1

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 1

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MGI:2145656, MGI:2145678

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hmbox1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129238	Chr14:65187287-65187335 (-)	9 bp
Tssr129237	Chr14:65187263-65187269 (-)	54 bp
Tssr129236	Chr14:65187179-65187200 (-)	130 bp
Tssr129235	Chr14:65187081-65187123 (-)	218 bp
Tssr129234	Chr14:65186779-65186819 (-)	521 bp
Tssr129233	Chr14:65186349-65186366 (-)	962 bp
Tssr129232	Chr14:65179729-65179734 (-)	7,588 bp
Tssr129231	Chr14:65050504-65050522 (-)	136,807 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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