Tmem184b MGI Mouse Gene Detail - MGI:2445179

Symbol

Tmem184b
Name

transmembrane protein 184b
Synonyms

4732495E13Rik

Feature Type

protein coding gene
IDs

MGI:2445179
NCBI Gene: 223693
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:79244884-79287503 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

2 experiments

SNPs within 2kb

1340 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445179	protein coding gene	Chr15:79244884-79287769 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022073	protein coding gene	Chr15:79620892-79667495 (-)
A/J	MGP_AJ_G0022034	protein coding gene	Chr15:76879520-76923273 (-)
AKR/J	MGP_AKRJ_G0022009	protein coding gene	Chr15:79024183-79070100 (-)
BALB/cJ	MGP_BALBcJ_G0022040	protein coding gene	Chr15:76871869-76916169 (-)
C3H/HeJ	MGP_C3HHeJ_G0021811	protein coding gene	Chr15:79019613-79063588 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022483	protein coding gene	Chr15:82773230-82819370 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020013	protein coding gene	Chr15:73360923-73405151 (-)
CAST/EiJ	MGP_CASTEiJ_G0021332	protein coding gene	Chr15:79720719-79767770 (-)
CBA/J	MGP_CBAJ_G0021776	protein coding gene	Chr15:85332671-85380115 (-)
DBA/2J	MGP_DBA2J_G0021905	protein coding gene	Chr15:76362268-76405820 (-)
FVB/NJ	MGP_FVBNJ_G0021883	protein coding gene	Chr15:75393719-75437974 (-)
LP/J	MGP_LPJ_G0021973	protein coding gene	Chr15:79812281-79858772 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021903	protein coding gene	Chr15:90456687-90501683 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022497	protein coding gene	Chr15:79038004-79083115 (-)
PWK/PhJ	MGP_PWKPhJ_G0021074	protein coding gene	Chr15:76371332-76416428 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020911	protein coding gene	Chr15:78849129-78898868 (-)
WSB/EiJ	MGP_WSBEiJ_G0021384	protein coding gene	Chr15:79420479-79468856 (-)

Human Ortholog

TMEM184B, transmembrane protein 184B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM184B, transmembrane protein 184B
Synonyms

C22orf5, FM08, HS5O6A, HSPC256, SLC51C2
Links

HGNC:1310

NCBI Gene ID: 25829

neXtProt AC: NX_Q9Y519

UniProt: Q9Y519
Chr Location

22q13.1; chr22:38216395-38273010 (-) GRCh38

MGI Vertebrate Homology

Tmem184b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TMEM184B
Gene Tree

Tmem184b

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References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

33
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Tmem184b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene-trapped allele exhibit delayed axon degeneration following peripheral nerve injury, progressive structural abnormalities at neuromuscular synapses, swellings within sensory terminals, sensory-motor dysfunction, and abnormal autophagy.

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

48
cDNA Data

87
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem184b

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All Sequences

90
RefSeq

24
UniProt

6
CCDS

CCDS27639.1, CCDS88803.1

Ensembl

ENSMUSG00000009035 (Evidence)
NCBI Gene

223693

			Length	Strain/Species	Flank
genomic	223693	NCBI Gene Model \| MGI Sequence Detail	42620	C57BL/6J	± kb
transcript	NM_001378998	RefSeq \| MGI Sequence Detail	3431	C57BL/6
polypeptide	Q8BG09	UniProt \| EBI \| MGI Sequence Detail	407	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016419 transmembrane protein 184B

(term hierarchy)
InterPro Domains

IPR005178 Organic solute transporter subunit alpha/Transmembrane protein 184

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All nucleic 87

cDNA 87

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem184b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135341	Chr15:79287747-79287778 (-)	-260 bp
Tssr135340	Chr15:79287448-79287509 (-)	24 bp
Tssr135339	Chr15:79287436-79287445 (-)	62 bp
Tssr135338	Chr15:79281062-79281079 (-)	6,432 bp
Tssr135337	Chr15:79281021-79281044 (-)	6,470 bp
Tssr135336	Chr15:79262798-79262845 (-)	24,681 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24