Rfx6 MGI Mouse Gene Detail - MGI:2445208

Symbol

Rfx6
Name

regulatory factor X, 6
Synonyms

4930572O07Rik, Rfxdc1

Feature Type

protein coding gene
IDs

MGI:2445208
NCBI Gene: 320995
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:51553856-51606525 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 25.74 cM
Mapping Data

1 experiment

SNPs within 2kb

1547 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445208	protein coding gene	Chr10:51553852-51606528 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017218	protein coding gene	Chr10:50820269-50879187 (+)
A/J	MGP_AJ_G0017194	protein coding gene	Chr10:49321998-49374455 (+)
AKR/J	MGP_AKRJ_G0017153	protein coding gene	Chr10:50230503-50285978 (+)
BALB/cJ	MGP_BALBcJ_G0017155	protein coding gene	Chr10:49421772-49474707 (+)
C3H/HeJ	MGP_C3HHeJ_G0016977	protein coding gene	Chr10:50514489-50568550 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017614	protein coding gene	Chr10:52422426-52476326 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015308	protein coding gene	Chr10:46628032-46680846 (+)
CAST/EiJ	MGP_CASTEiJ_G0016551	protein coding gene	Chr10:50664186-50723704 (+)
CBA/J	MGP_CBAJ_G0016950	protein coding gene	Chr10:54681477-54746326 (+)
DBA/2J	MGP_DBA2J_G0017055	protein coding gene	Chr10:48750644-48803368 (+)
FVB/NJ	MGP_FVBNJ_G0017049	protein coding gene	Chr10:48097601-48150167 (+)
LP/J	MGP_LPJ_G0017130	protein coding gene	Chr10:50855682-50924988 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017078	protein coding gene	Chr10:56599725-56659753 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017649	protein coding gene	Chr10:50181430-50236169 (+)
PWK/PhJ	MGP_PWKPhJ_G0016332	protein coding gene	Chr10:48625446-48679558 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016117	protein coding gene	Chr10:49807049-49866621 (+)
WSB/EiJ	MGP_WSBEiJ_G0016616	protein coding gene	Chr10:50401061-50459912 (+)

Human Ortholog

RFX6, regulatory factor X6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RFX6, regulatory factor X6
Synonyms

dJ955L16.1, MTCHRS, MTFS, RFXDC1
Links

HGNC:21478

NCBI Gene ID: 222546

neXtProt AC: NX_Q8HWS3

UniProt: Q8HWS3
Chr Location

6q22.1; chr6:116877212-116932161 (+) GRCh38

MGI Vertebrate Homology

Rfx6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RFX6
Gene Tree

Rfx6

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Rfx6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes fail to feed normally, show small bowel obstruction and die within 2 days of birth. Mutants fail to generate any of the normal islet cell types except for pancreatic-polypeptide-producing cells. Some display a reduced pancreas size; however, primary cilia formation in islets is normal.

less

All GO Annotations

27
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

30
cDNA Data

7
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RFX6

Xenbase rfx6

ZFIN rfx6

less

All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS23835.1, CCDS48558.1

Ensembl

ENSMUSG00000019900 (Evidence)
NCBI Gene

320995

			Length	Strain/Species	Flank
genomic	320995	NCBI Gene Model \| MGI Sequence Detail	52670	C57BL/6J	± kb
transcript	NM_001159389	RefSeq \| MGI Sequence Detail	3457	C57BL/6
polypeptide	Q8C7R7	UniProt \| EBI \| MGI Sequence Detail	927	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013928 DNA-binding protein RFX6

(term hierarchy)
InterPro Domains

IPR003150 DNA-binding RFX-type winged-helix domain

IPR039779 RFX-like DNA-binding protein

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

less

All nucleic 12

Genomic 2

cDNA 7

Primer pair 2

Other 1

Microarray probesets 1

Summaries

All 50

Developmental Gene Expression 11

Gene Ontology 5

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rfx6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93294	Chr10:51553862-51553885 (+)	18 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24