Xpnpep3 MGI Mouse Gene Detail - MGI:2445217 - X-prolyl aminopeptidase 3, mitochondrial

Symbol

Xpnpep3
Name

X-prolyl aminopeptidase 3, mitochondrial
Synonyms

E430012M05Rik

Feature Type

protein coding gene
IDs

MGI:2445217
NCBI Gene: 321003
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:81284339-81341683 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.08 cM
Mapping Data

1 experiment

SNPs within 2kb

1149 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445217	protein coding gene	Chr15:81284282-81341683 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022111	protein coding gene	Chr15:81822018-81880632 (+)
A/J	MGP_AJ_G0022072	protein coding gene	Chr15:78948079-79009917 (+)
AKR/J	MGP_AKRJ_G0022047	protein coding gene	Chr15:81144304-81196932 (+)
BALB/cJ	MGP_BALBcJ_G0022078	protein coding gene	Chr15:78976871-79043307 (+)
C3H/HeJ	MGP_C3HHeJ_G0021849	protein coding gene	Chr15:81138611-81201323 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022521	protein coding gene	Chr15:85016344-85081007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020051	protein coding gene	Chr15:75418867-75473171 (+)
CAST/EiJ	MGP_CASTEiJ_G0021370	protein coding gene	Chr15:81895604-81957529 (+)
CBA/J	MGP_CBAJ_G0021814	protein coding gene	Chr15:87671234-87739823 (+)
DBA/2J	MGP_DBA2J_G0021943	protein coding gene	Chr15:78430694-78487073 (+)
FVB/NJ	MGP_FVBNJ_G0021921	protein coding gene	Chr15:77471026-77523706 (+)
LP/J	MGP_LPJ_G0022011	protein coding gene	Chr15:81980511-82037274 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021941	protein coding gene	Chr15:92648944-92708801 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022535	protein coding gene	Chr15:81208960-81270155 (+)
PWK/PhJ	MGP_PWKPhJ_G0021112	protein coding gene	Chr15:78458908-78521095 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020949	protein coding gene	Chr15:81004773-81065664 (+)
WSB/EiJ	MGP_WSBEiJ_G0021422	protein coding gene	Chr15:81635068-81693338 (+)

Human Ortholog

XPNPEP3, X-prolyl aminopeptidase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPNPEP3, X-prolyl aminopeptidase 3
Synonyms

APP3, ICP55, NPHPL1
Links

HGNC:28052

NCBI Gene ID: 63929

neXtProt AC: NX_Q9NQH7

UniProt: Q9NQH7
Chr Location

22q13.2; chr22:40857077-40932815 (+) GRCh38

MGI Vertebrate Homology

Xpnpep3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XPNPEP3
Gene Tree

Xpnpep3

Diseases

1 with human XPNPEP3 associations

				Human Disease	Mouse Models
				nephronophthisis-like nephropathy 1 IDs nephronophthisis-like nephropathy 1 DOID:0111117 OMIM:613159

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Gene trapped

29
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Xpnpep3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

47
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xpnpep3

ZFIN xpnpep3

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS27668.1, CCDS84182.1

Ensembl

ENSMUSG00000022401 (Evidence)
NCBI Gene

321003

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022401	Ensembl Gene Model \| MGI Sequence Detail	57345	C57BL/6J	± kb
transcript	ENSMUST00000163754	Ensembl \| MGI Sequence Detail	6058	Not Applicable
polypeptide	ENSMUSP00000132822	Ensembl \| MGI Sequence Detail	506	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031424 Xaa-Pro aminopeptidase 3

(term hierarchy)
EC

3.4.11.9
InterPro Domains

IPR007865 Aminopeptidase P, N-terminal

IPR036005 Creatinase/aminopeptidase-like

IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal

IPR000994 Peptidase M24

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xpnpep3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132265	Chr15:81284333-81284416 (+)	36 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24