Scml4 MGI Mouse Gene Detail - MGI:2446140 - Scm polycomb group protein like 4

Symbol

Scml4
Name

Scm polycomb group protein like 4
Synonyms

MGC:49264

Feature Type

protein coding gene
IDs

MGI:2446140
NCBI Gene: 268297
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:42736366-42836776 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.89 cM
Mapping Data

1 experiment

SNPs within 2kb

3382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446140	protein coding gene	Chr10:42736314-42836778 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017189	protein coding gene	Chr10:41590270-41696760 (+)
A/J	MGP_AJ_G0017166	protein coding gene	Chr10:40429548-40534258 (+)
AKR/J	MGP_AKRJ_G0017126	protein coding gene	Chr10:41037819-41142824 (+)
BALB/cJ	MGP_BALBcJ_G0017128	protein coding gene	Chr10:40484609-40584788 (+)
C3H/HeJ	MGP_C3HHeJ_G0016949	protein coding gene	Chr10:41394980-41505807 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017587	protein coding gene	Chr10:42859257-42966432 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015283	protein coding gene	Chr10:38279475-38374483 (+)
CAST/EiJ	MGP_CASTEiJ_G0016528	protein coding gene	Chr10:41600690-41705969 (+)
CBA/J	MGP_CBAJ_G0016923	protein coding gene	Chr10:44849670-44952291 (+)
DBA/2J	MGP_DBA2J_G0017028	protein coding gene	Chr10:39913694-40014286 (+)
FVB/NJ	MGP_FVBNJ_G0017023	protein coding gene	Chr10:39404517-39504305 (+)
LP/J	MGP_LPJ_G0017105	protein coding gene	Chr10:41599872-41705629 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017053	protein coding gene	Chr10:45564805-45670681 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017624	protein coding gene	Chr10:41030471-41142413 (+)
PWK/PhJ	MGP_PWKPhJ_G0016308	protein coding gene	Chr10:39788018-39890110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016092	protein coding gene	Chr10:40862702-40978986 (+)
WSB/EiJ	MGP_WSBEiJ_G0016591	protein coding gene	Chr10:41327445-41436121 (+)

Human Ortholog

SCML4, Scm polycomb group protein like 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCML4, Scm polycomb group protein like 4
Synonyms

dJ47M23.1
Links

HGNC:21397

NCBI Gene ID: 256380

neXtProt AC: NX_Q8N228

UniProt: Q8N228
Chr Location

6q21; chr6:107702154-107846038 (-) GRCh38

MGI Vertebrate Homology

Scml4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCML4
Gene Tree

Scml4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Genomic Mutations

2 involving Scml4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

36
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scml4

ZFIN scml4

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All Sequences

77
RefSeq

22
UniProt

5
CCDS

CCDS23816.1, CCDS87998.1, CCDS87999.1

Ensembl

ENSMUSG00000044770 (Evidence)
NCBI Gene

268297

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044770	Ensembl Gene Model \| MGI Sequence Detail	100411	C57BL/6J	± kb
transcript	ENSMUST00000063063	Ensembl \| MGI Sequence Detail	4885	Not Applicable
polypeptide	ENSMUSP00000053157	Ensembl \| MGI Sequence Detail	408	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014521 sex comb on midleg-like protein 4

(term hierarchy)
InterPro Domains

IPR050548 Polycomb group and chromatin remodeling factors

IPR033763 Polycomb group protein, RNA binding region

IPR047531 Sex comb on midleg-like, SAM domain

IPR021987 SLED domain

IPR038348 SLED domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 37

cDNA 36

Primer pair 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Scml4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93112	Chr10:42736344-42736373 (+)	-7 bp
Tssr93113	Chr10:42736620-42736623 (+)	256 bp
Tssr93114	Chr10:42736644-42736672 (+)	292 bp
Tssr93115	Chr10:42736678-42736688 (+)	317 bp
Tssr93116	Chr10:42736691-42736710 (+)	335 bp
Tssr93117	Chr10:42736737-42736742 (+)	374 bp
Tssr93118	Chr10:42736744-42736755 (+)	384 bp
Tssr93119	Chr10:42736772-42736806 (+)	423 bp
Tssr93120	Chr10:42737574-42737584 (+)	1,213 bp
Tssr93121	Chr10:42773863-42773884 (+)	37,508 bp
Tssr93122	Chr10:42773915-42773927 (+)	37,555 bp
Tssr93123	Chr10:42777616-42777633 (+)	41,259 bp
Tssr93124	Chr10:42777646-42777665 (+)	41,290 bp
Tssr93125	Chr10:42810906-42810913 (+)	74,544 bp
Tssr93126	Chr10:42816408-42816440 (+)	80,058 bp
Tssr93127	Chr10:42816450-42816480 (+)	80,099 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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