Anks1 MGI Mouse Gene Detail - MGI:2446180 - ankyrin repeat and SAM domain containing 1

Symbol

Anks1
Name

ankyrin repeat and SAM domain containing 1
Synonyms

MGC:59413, mKIAA0229, Odin

Feature Type

protein coding gene
IDs

MGI:2446180
NCBI Gene: 224650
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:28128280-28281749 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.60 cM
Mapping Data

1 experiment

SNPs within 2kb

1406 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446180	protein coding gene	Chr17:28128273-28281753 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023431	protein coding gene	Chr17:27251296-27409778 (+)
A/J	MGP_AJ_G0023389	protein coding gene	Chr17:26375009-26542387 (+)
AKR/J	MGP_AKRJ_G0023354	protein coding gene	Chr17:26555898-26711517 (+)
BALB/cJ	MGP_BALBcJ_G0023394	protein coding gene	Chr17:26650043-26803426 (+)
C3H/HeJ	MGP_C3HHeJ_G0023155	protein coding gene	Chr17:26934038-27091796 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023836	protein coding gene	Chr17:28378700-28534601 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021311	protein coding gene	Chr17:23758472-23912701 (+)
CAST/EiJ	MGP_CASTEiJ_G0022656	protein coding gene	Chr17:26908550-27070644 (+)
CBA/J	MGP_CBAJ_G0023129	protein coding gene	Chr17:29372802-29535449 (+)
DBA/2J	MGP_DBA2J_G0023260	protein coding gene	Chr17:25938012-26091573 (+)
FVB/NJ	MGP_FVBNJ_G0023230	protein coding gene	Chr17:25732123-25886023 (+)
LP/J	MGP_LPJ_G0023338	protein coding gene	Chr17:27514758-27673073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023248	protein coding gene	Chr17:28836548-28992660 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023878	protein coding gene	Chr17:26974311-27132717 (+)
PWK/PhJ	MGP_PWKPhJ_G0022406	protein coding gene	Chr17:24737255-24893615 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022224	protein coding gene	Chr17:24983376-25141394 (+)
WSB/EiJ	MGP_WSBEiJ_G0022718	protein coding gene	Chr17:26971064-27126600 (+)

Human Ortholog

ANKS1A, ankyrin repeat and sterile alpha motif domain containing 1A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKS1A, ankyrin repeat and sterile alpha motif domain containing 1A
Synonyms

ANKS1
Links

HGNC:20961

NCBI Gene ID: 23294

neXtProt AC: NX_Q92625

UniProt: Q92625
Chr Location

6p21.31; chr6:34889255-35097990 (+) GRCh38

MGI Vertebrate Homology

Anks1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANKS1A
Gene Tree

Anks1

less

Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

2
Gene trapped

25
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a gene trapped allele exhibit a normal phenotype.

less

All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

23
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

93
RefSeq

36
UniProt

1
CCDS

CCDS37525.1, CCDS70777.1, CCDS70778.1, CCDS89037.1

Ensembl

ENSMUSG00000024219 (Evidence)
NCBI Gene

224650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024219	Ensembl Gene Model \| MGI Sequence Detail	153470	C57BL/6J	± kb
transcript	ENSMUST00000025058	Ensembl \| MGI Sequence Detail	6846	Not Applicable
polypeptide	ENSMUSP00000025058	Ensembl \| MGI Sequence Detail	1189	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000004051 ankyrin repeat and SAM domain-containing protein 1A

(term hierarchy)

less

All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 21
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Anks1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143371	Chr17:28128261-28128288 (+)	-5 bp
Tssr143372	Chr17:28128311-28128383 (+)	67 bp
Tssr143373	Chr17:28198040-28198064 (+)	69,772 bp
Tssr143374	Chr17:28226320-28226383 (+)	98,072 bp
Tssr143375	Chr17:28226445-28226476 (+)	98,181 bp
Tssr143376	Chr17:28226495-28226514 (+)	98,225 bp
Tssr143377	Chr17:28226556-28226570 (+)	98,283 bp
Tssr143378	Chr17:28226622-28226668 (+)	98,365 bp
Tssr143379	Chr17:28226669-28226678 (+)	98,394 bp
Tssr143380	Chr17:28226965-28227002 (+)	98,704 bp
Tssr143381	Chr17:28227253-28227281 (+)	98,987 bp
Tssr143382	Chr17:28241142-28241172 (+)	112,877 bp
Tssr143383	Chr17:28259754-28259785 (+)	131,490 bp
Tssr143384	Chr17:28259788-28259806 (+)	131,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24