Slc37a1 MGI Mouse Gene Detail - MGI:2446181 - solute carrier family 37 (glycerol-3-phosphate transporter), member 1

Symbol

Slc37a1
Name

solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms

G3PP, MGC:28167

Feature Type

protein coding gene
IDs

MGI:2446181
NCBI Gene: 224674
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:31505766-31569713 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 16.03 cM
Mapping Data

1 experiment

SNPs within 2kb

1847 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446181	protein coding gene	Chr17:31495722-31569713 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023487	protein coding gene	Chr17:31052176-31113318 (+)
A/J	MGP_AJ_G0023445	protein coding gene	Chr17:30033242-30089937 (+)
AKR/J	MGP_AKRJ_G0023410	protein coding gene	Chr17:30285900-30343517 (+)
BALB/cJ	MGP_BALBcJ_G0023450	protein coding gene	Chr17:30133424-30190045 (+)
C3H/HeJ	MGP_C3HHeJ_G0023211	protein coding gene	Chr17:30664535-30722778 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023892	protein coding gene	Chr17:32116236-32181578 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021366	protein coding gene	Chr17:27167495-27224390 (+)
CAST/EiJ	MGP_CASTEiJ_G0022712	protein coding gene	Chr17:30718549-30769765 (+)
CBA/J	MGP_CBAJ_G0023186	protein coding gene	Chr17:33535961-33594396 (+)
DBA/2J	MGP_DBA2J_G0023316	protein coding gene	Chr17:29440978-29497112 (+)
FVB/NJ	MGP_FVBNJ_G0023286	protein coding gene	Chr17:29230111-29286486 (+)
LP/J	MGP_LPJ_G0023394	protein coding gene	Chr17:31269076-31326766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023304	protein coding gene	Chr17:32613330-32677561 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023934	protein coding gene	Chr17:30658010-30716025 (+)
PWK/PhJ	MGP_PWKPhJ_G0022462	protein coding gene	Chr17:28291701-28360717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022280	protein coding gene	Chr17:28641067-28696651 (+)
WSB/EiJ	MGP_WSBEiJ_G0022774	protein coding gene	Chr17:30619510-30677954 (+)

Human Ortholog

SLC37A1, solute carrier family 37 member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC37A1, solute carrier family 37 member 1
Synonyms

G3PP, SPX1
Links

HGNC:11024

NCBI Gene ID: 54020

neXtProt AC: NX_P57057

UniProt: P57057
Chr Location

21q22.3; chr21:42496008-42581440 (+) GRCh38

MGI Vertebrate Homology

Slc37a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC37A1
Protein SuperFamily

Hexose_phosphate_transp
Gene Tree

Slc37a1

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References

3 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Endonuclease-mediated

1
Gene trapped

48
Targeted

7
Genomic Mutations

4 involving Slc37a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc37a1

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All Sequences

83
RefSeq

14
UniProt

10
CCDS

CCDS37548.1

Ensembl

ENSMUSG00000024036 (Evidence)
NCBI Gene

224674

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024036	Ensembl Gene Model \| MGI Sequence Detail	63948	C57BL/6J	± kb
transcript	ENSMUST00000171233	Ensembl \| MGI Sequence Detail	2972	Not Applicable
polypeptide	ENSMUSP00000126111	Ensembl \| MGI Sequence Detail	531	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000015114 glucose-6-phosphate exchanger SLC37A1

(term hierarchy)
InterPro Domains

IPR044740 Glucose-6-phosphate exchanger SLC37A1/ SLC37A2

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR000849 Sugar phosphate transporter

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 4

Summaries

All 59

Developmental Gene Expression 2

Diseases 3

Gene Ontology 3

Phenotypes 36
Earliest

J:80501 Gitton Y, et al., A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Slc37a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5083	Chr17:31514780-31514793 (+)	9,021 bp
Tssr143657	Chr17:31515165-31515227 (+)	9,430 bp
Tssr143658	Chr17:31515696-31515768 (+)	9,966 bp
Tssr143659	Chr17:31515770-31515790 (+)	10,014 bp
Tssr143660	Chr17:31515960-31515973 (+)	10,201 bp
Tssr143661	Chr17:31538831-31538856 (+)	33,078 bp
Tssr143662	Chr17:31541114-31541127 (+)	35,355 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24