Lpgat1 MGI Mouse Gene Detail - MGI:2446186 - lysophosphatidylglycerol acyltransferase 1

Symbol

Lpgat1
Name

lysophosphatidylglycerol acyltransferase 1
Synonyms

MGC:18768

Feature Type

protein coding gene
IDs

MGI:2446186
NCBI Gene: 226856
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:191449946-191516367 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 96.78 cM
Mapping Data

2 experiments

SNPs within 2kb

1331 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446186	protein coding gene	Chr1:191449682-191516367 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016947	protein coding gene	Chr1:198781335-198854172 (+)
A/J	MGP_AJ_G0016926	protein coding gene	Chr1:190626734-190693801 (+)
AKR/J	MGP_AKRJ_G0016891	protein coding gene	Chr1:196295986-196366382 (+)
BALB/cJ	MGP_BALBcJ_G0016884	protein coding gene	Chr1:191307674-191375098 (+)
C3H/HeJ	MGP_C3HHeJ_G0016708	protein coding gene	Chr1:197133855-197206754 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017347	protein coding gene	Chr1:205120257-205196645 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015054	protein coding gene	Chr1:181529418-181595597 (+)
CAST/EiJ	MGP_CASTEiJ_G0016291	protein coding gene	Chr1:196730900-196799526 (+)
CBA/J	MGP_CBAJ_G0016682	protein coding gene	Chr1:212715357-212795084 (+)
DBA/2J	MGP_DBA2J_G0016788	protein coding gene	Chr1:189346239-189418277 (+)
FVB/NJ	MGP_FVBNJ_G0016784	protein coding gene	Chr1:187474443-187542402 (+)
LP/J	MGP_LPJ_G0016863	protein coding gene	Chr1:199972640-200045310 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016816	protein coding gene	Chr1:219384541-219458797 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017384	protein coding gene	Chr1:196154039-196226432 (+)
PWK/PhJ	MGP_PWKPhJ_G0016078	protein coding gene	Chr1:188641319-188712261 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015854	protein coding gene	Chr1:195167259-195229386 (+)
WSB/EiJ	MGP_WSBEiJ_G0016353	protein coding gene	Chr1:196388370-196471624 (+)

Human Ortholog

LPGAT1, lysophosphatidylglycerol acyltransferase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPGAT1, lysophosphatidylglycerol acyltransferase 1
Synonyms

FAM34A, FAM34A1, LPLAT7, NET8
Links

HGNC:28985

NCBI Gene ID: 9926

neXtProt AC: NX_Q92604

UniProt: Q92604
Chr Location

1q32.3; chr1:211743457-211830763 (-) GRCh38

MGI Vertebrate Homology

Lpgat1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPGAT1
Gene Tree

Lpgat1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Gene trapped

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

96
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpgat1

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All Sequences

76
RefSeq

18
UniProt

7
CCDS

CCDS15622.1, CCDS48488.1

Ensembl

ENSMUSG00000026623 (Evidence)
NCBI Gene

226856

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026623	Ensembl Gene Model \| MGI Sequence Detail	66422	C57BL/6J	± kb
transcript	ENSMUST00000110856	Ensembl \| MGI Sequence Detail	2792	Not Applicable
polypeptide	ENSMUSP00000106480	Ensembl \| MGI Sequence Detail	409	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009893 acyl-CoA:lysophosphatidylglycerol acyltransferase 1

(term hierarchy)
EC

2.3.1.-, 2.3.1.22, 2.3.1.62
InterPro Domains

IPR032098 Acyltransferase, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase
GlyGen

Q91YX5 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 13

Microarray probesets 10

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MGI:2138316, MGI:2138562

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 10
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lpgat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10776	Chr1:191449992-191450016 (+)	58 bp
Tssr10777	Chr1:191450105-191450142 (+)	178 bp
Tssr10778	Chr1:191450147-191450173 (+)	214 bp
Tssr10779	Chr1:191450182-191450202 (+)	246 bp
Tssr10780	Chr1:191450367-191450425 (+)	450 bp
Tssr10781	Chr1:191450490-191450506 (+)	552 bp
Tssr10782	Chr1:191450507-191450543 (+)	579 bp
Tssr10783	Chr1:191451276-191451341 (+)	1,363 bp
Tssr10784	Chr1:191475227-191475252 (+)	25,294 bp
Tssr10785	Chr1:191511789-191511793 (+)	61,845 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24