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Dennd4b Gene Detail
Summary
  • Symbol
    Dennd4b
  • Name
    DENN domain containing 4B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446201
    NCBI Gene: 229541
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90172492-90187976 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446201
 protein coding gene Chr3:90172281-90187976 (+)
129S1/SvImJ ENSMUSG00200036470
 protein coding gene Chr3:87029175-87043330 (+)
A/J ENSMUSG00195052234
 protein coding gene Chr3:87044336-87058495 (+)
AKR/J ENSMUSG00220047325
 protein coding gene Chr3:86998848-87013008 (+)
BALB/cJ ENSMUSG00180044343
 protein coding gene Chr3:87136283-87150445 (+)
C3H/HeJ ENSMUSG00175044442
 protein coding gene Chr3:86976889-86991049 (+)
C57BL/6NJ ENSMUSG00215047773
 protein coding gene Chr3:87416942-87431097 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025232
 protein coding gene Chr3:83045705-83060993 (+)
CAST/EiJ ENSTCUG00005043331
 protein coding gene Chr3:86499100-86513254 (+)
CBA/J ENSMUSG00210034870
 protein coding gene Chr3:87114536-87128696 (+)
DBA/2J ENSMUSG00185052335
 protein coding gene Chr3:87224554-87238707 (+)
FVB/NJ ENSMUSG00205043989
 protein coding gene Chr3:86038537-86052696 (+)
JF1/MsJ ENSUMUG00000046814
 protein coding gene Chr3:86837877-86852031 (+)
LP/J ENSMUSG00230035055
 protein coding gene Chr3:89250408-89264563 (+)
NOD/ShiLtJ ENSMUSG00190041495
 protein coding gene Chr3:87510254-87524416 (+)
NZO/HlLtJ ENSMUSG00225009560
 protein coding gene Chr3:92008637-92022789 (+)
PWK/PhJ ENSLUMG00010048191
 protein coding gene Chr3:86871133-86885315 (+)
SPRET/EiJ ENSMSPG00010047335
 protein coding gene Chr3:87747244-87762711 (+)
WSB/EiJ ENSIUOG00005045848
 protein coding gene Chr3:87530078-87544244 (+)



Homology
more
  • Human Ortholog
    DENND4B, DENN domain containing 4B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND4B, DENN domain containing 4B
  • Synonyms
    KIAA0476
  • Links
    NCBI Gene ID: 9909
    UniProt: O75064

  • Chr Location
    1q21.3; chr1:153928864-153946894 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    50
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042404 Ensembl Gene Model | MGI Sequence Detail 15485 C57BL/6J ±  kb
transcript ENSMUST00000098914 Ensembl | MGI Sequence Detail 5423 Not Applicable  
polypeptide ENSMUSP00000096514 Ensembl | MGI Sequence Detail 1510 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Diseases 1
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory