Fbxo2 MGI Mouse Gene Detail - MGI:2446216

Symbol

Fbxo2
Name

F-box protein 2
Synonyms

Fbs1, FBX2, MGC:54895, NFB42, Prpl4

Feature Type

protein coding gene
IDs

MGI:2446216
NCBI Gene: 230904
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:148245078-148250881 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 78.68 cM
Mapping Data

2 experiments

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446216	protein coding gene	Chr4:148244605-148250881 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029121	protein coding gene	Chr4:151852432-151858935 (+)
A/J	MGP_AJ_G0029086	protein coding gene	Chr4:145579989-145585520 (+)
AKR/J	MGP_AKRJ_G0029034	protein coding gene	Chr4:149546386-149553500 (+)
BALB/cJ	MGP_BALBcJ_G0029102	protein coding gene	Chr4:146089954-146095732 (+)
C3H/HeJ	MGP_C3HHeJ_G0028823	protein coding gene	Chr4:150106854-150112652 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029551	protein coding gene	Chr4:157390703-157396869 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026797	protein coding gene	Chr4:138003097-138008688 (+)
CAST/EiJ	MGP_CASTEiJ_G0028236	protein coding gene	Chr4:147302240-147309264 (+)
CBA/J	MGP_CBAJ_G0028785	protein coding gene	Chr4:161929994-161935779 (+)
DBA/2J	MGP_DBA2J_G0028933	protein coding gene	Chr4:145688668-145695977 (+)
FVB/NJ	MGP_FVBNJ_G0028898	protein coding gene	Chr4:144778887-144785555 (+)
LP/J	MGP_LPJ_G0029024	protein coding gene	Chr4:151818448-151827942 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028925	protein coding gene	Chr4:165286178-165291939 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029583	protein coding gene	Chr4:150028808-150036395 (+)
PWK/PhJ	MGP_PWKPhJ_G0027956	protein coding gene	Chr4:141676249-141682207 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027790	protein coding gene	Chr4:144292378-144300491 (+)
WSB/EiJ	MGP_WSBEiJ_G0028316	protein coding gene	Chr4:150190270-150197005 (+)

Human Ortholog

FBXO2, F-box protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO2, F-box protein 2
Synonyms

FBG1, Fbs1, FBX2, NFB42, OCP1
Links

HGNC:13581

NCBI Gene ID: 26232

neXtProt AC: NX_Q9UK22

UniProt: Q9UK22
Chr Location

1p36.22; chr1:11637018-11655785 (-) GRCh38

MGI Vertebrate Homology

Fbxo2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO2
Gene Tree

Fbxo2

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Targeted

9
Genomic Mutations

2 involving Fbxo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted mutation are behaviorally normal but display accelerated, age-related hearing loss associated with cochlear degeneration. Cellular degeneration begins at 2 months in the supporting cells of the organ of Corti and progresses to cochlear hair cells and the spiral ganglion.

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All GO Annotations

36
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

15
cDNA Data

21
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FBXO2

ZFIN fbxo2

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All Sequences

37
RefSeq

7
UniProt

2
CCDS

CCDS18935.1

Ensembl

ENSMUSG00000041556 (Evidence)
NCBI Gene

230904

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041556	Ensembl Gene Model \| MGI Sequence Detail	5804	C57BL/6J	± kb
transcript	ENSMUST00000047951	Ensembl \| MGI Sequence Detail	1288	Not Applicable
polypeptide	ENSMUSP00000037377	Ensembl \| MGI Sequence Detail	297	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007393 F-box only protein 2

(term hierarchy)
PDB

1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2, 5B4N
InterPro Domains

IPR007397 F-box associated (FBA) domain

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR039752 F-box only protein

IPR008979 Galactose-binding-like domain superfamily
GlyGen

Q80UW2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 21

Other 1

Microarray probesets 3

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MGI:892993

Summaries

All 54

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 20
Earliest

J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40263	Chr4:148244604-148244653 (+)	-449 bp
Tssr40264	Chr4:148245070-148245087 (+)	1 bp
Tssr40265	Chr4:148245088-148245109 (+)	21 bp
Tssr40266	Chr4:148245113-148245137 (+)	47 bp
Tssr40267	Chr4:148248674-148248696 (+)	3,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24