Mosmo MGI Mouse Gene Detail - MGI:2446240

Symbol

Mosmo
Name

modulator of smoothened
Synonyms

BC030336, MGC:40669

Feature Type

protein coding gene
IDs

MGI:2446240
NCBI Gene: 233812
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:120276841-120334077 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.90 cM
Mapping Data

2 experiments

SNPs within 2kb

1287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446240	protein coding gene	Chr7:120276814-120334079 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032932	protein coding gene	Chr7:124661180-124724345 (+)
A/J	MGP_AJ_G0032915	protein coding gene	Chr7:121419384-121477856 (+)
AKR/J	MGP_AKRJ_G0032847	protein coding gene	Chr7:124537761-124596851 (+)
BALB/cJ	MGP_BALBcJ_G0032920	protein coding gene	Chr7:121140403-121198908 (+)
C3H/HeJ	MGP_C3HHeJ_G0032630	protein coding gene	Chr7:124441653-124501120 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033426	protein coding gene	Chr7:129616304-129678170 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030398	protein coding gene	Chr7:122806549-122866377 (+)
CAST/EiJ	MGP_CASTEiJ_G0031958	protein coding gene	Chr7:116197240-116262174 (+)
CBA/J	MGP_CBAJ_G0032603	protein coding gene	Chr7:133934907-133996548 (+)
DBA/2J	MGP_DBA2J_G0032755	protein coding gene	Chr7:119460848-119519446 (+)
FVB/NJ	MGP_FVBNJ_G0032708	protein coding gene	Chr7:119317298-119377492 (+)
LP/J	MGP_LPJ_G0032849	protein coding gene	Chr7:126104670-126174588 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032740	protein coding gene	Chr7:135407018-135465292 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033446	protein coding gene	Chr7:123525556-123583650 (+)
PWK/PhJ	MGP_PWKPhJ_G0031666	protein coding gene	Chr7:112388201-112446930 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031512	protein coding gene	Chr7:110272803-110343437 (+)
WSB/EiJ	MGP_WSBEiJ_G0032071	protein coding gene	Chr7:124451509-124512052 (+)

Human Ortholog

MOSMO, modulator of smoothened

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MOSMO, modulator of smoothened
Synonyms

ATTHOG, BC030336, C16orf52
Links

HGNC:27087

NCBI Gene ID: 730094

neXtProt AC: NX_Q8NHV5

UniProt: Q8NHV5
Chr Location

16p12.2; chr16:22007638-22092652 (+) GRCh38

MGI Vertebrate Homology

Mosmo stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MOSMO
Gene Tree

Mosmo

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

17
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit severe developmental defects, including heterotaxy, skeletal abnormalities and congenital heart defects and most die by E14.5.

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All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

40
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mosmo

ZFIN mosmoa, mosmob

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All Sequences

56
RefSeq

8
UniProt

5
CCDS

CCDS52381.1

Ensembl

ENSMUSG00000046096 (Evidence)
NCBI Gene

233812

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046096	Ensembl Gene Model \| MGI Sequence Detail	57237	C57BL/6J	± kb
transcript	ENSMUST00000060175	Ensembl \| MGI Sequence Detail	4831	Not Applicable
polypeptide	ENSMUSP00000055934	Ensembl \| MGI Sequence Detail	167	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000059967 modulator of smoothened protein

(term hierarchy)
InterPro Domains

IPR037663 Modulator of smoothened protein
GlyGen

Q8C784 1 site

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All nucleic 42

cDNA 40

Primer pair 1

Other 1

Microarray probesets 3

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MGI:6114012

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:311933 Kong JH, et al., Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867

TSS for Mosmo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68789	Chr7:120276802-120276853 (+)	-13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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