Pced1b Gene Detail

Summary

• Symbol
  Pced1b
• Name
  PC-esterase domain containing 1B
• Synonyms
  Fam113b

• Feature Type
  protein coding gene
• IDs
  MGI:2446270
  NCBI Gene: 239647
• Alliance
  gene page
• Transcription Start Sites
  21 TSS

Location &
Maps

• Sequence Map
  Chr15:97144988-97283561 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 52.91 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  4111 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446270	protein coding gene	Chr15:97143563-97283574 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022275	protein coding gene	Chr15:98891541-99038743 (+)
A/J	MGP_AJ_G0022234	protein coding gene	Chr15:94988644-95129286 (+)
AKR/J	MGP_AKRJ_G0022209	protein coding gene	Chr15:97867234-98013465 (+)
BALB/cJ	MGP_BALBcJ_G0022240	protein coding gene	Chr15:95203918-95347938 (+)
C3H/HeJ	MGP_C3HHeJ_G0022010	protein coding gene	Chr15:97898385-98053472 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022685	protein coding gene	Chr15:102534634-102688365 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020211	protein coding gene	Chr15:90956829-91094573 (+)
CAST/EiJ	MGP_CASTEiJ_G0021532	protein coding gene	Chr15:98788676-98946517 (+)
CBA/J	MGP_CBAJ_G0021977	protein coding gene	Chr15:105976089-106132727 (+)
DBA/2J	MGP_DBA2J_G0022104	protein coding gene	Chr15:94432196-94577316 (+)
FVB/NJ	MGP_FVBNJ_G0022083	protein coding gene	Chr15:93459965-93572634 (+)
LP/J	MGP_LPJ_G0022175	protein coding gene	Chr15:99001026-99147395 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022103	protein coding gene	Chr15:110123419-110277366 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022700	protein coding gene	Chr15:97984500-98136924 (+)
PWK/PhJ	MGP_PWKPhJ_G0021273	protein coding gene	Chr15:94525301-94670190 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021107	protein coding gene	Chr15:97779860-97936091 (+)
WSB/EiJ	MGP_WSBEiJ_G0021581	protein coding gene	Chr15:98509804-98662016 (+)

Homology

• Human Ortholog
  PCED1B, PC-esterase domain containing 1B

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PCED1B, PC-esterase domain containing 1B
  
• Synonyms
  FAM113B
• Links
  HGNC:28255

  NCBI Gene ID: 91523

  neXtProt AC: NX_Q96HM7

  UniProt: Q96HM7

  
  
• Chr Location
  12q13.11; chr12:47079603-47236662 (+)  GRCh38

---

• MGI Vertebrate Homology
  Pced1b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: PCED1B
• Gene Tree
  Pced1b
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  26 phenotype references
  

• All Mutations and Alleles
  70
• Chemically induced (other)
  1
• Gene trapped
  65
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  3 involving Pced1b
• Find Mice (IMSR)
  110 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  14

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  68
• RefSeq
  34
• UniProt
  2
• CCDS
  CCDS27781.1

• Ensembl
  ENSMUSG00000044250 (Evidence)
• NCBI Gene
  239647

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000044250	Ensembl Gene Model | MGI Sequence Detail	138574	C57BL/6J
transcript	ENSMUST00000228521	Ensembl | MGI Sequence Detail	1790	Not Applicable
polypeptide	ENSMUSP00000154814	Ensembl | MGI Sequence Detail	433	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000030589 PC-esterase domain-containing protein 1B
  (term hierarchy)
• InterPro Domains
  IPR036514 SGNH hydrolase superfamily

Molecular
Reagents

• All nucleic 14

  cDNA 14

  
  

  Microarray probesets 2

References

• Summaries
  All 42

  Diseases 1

  Phenotypes 26
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Pced1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132851	Chr15:97143558-97143567 (+)	-1,425 bp
Tssr132852	Chr15:97144839-97144885 (+)	-126 bp
Tssr132853	Chr15:97144892-97144933 (+)	-75 bp
Tssr132854	Chr15:97145272-97145329 (+)	313 bp
Tssr132855	Chr15:97259015-97259036 (+)	114,038 bp
Tssr132856	Chr15:97259061-97259106 (+)	114,096 bp
Tssr132857	Chr15:97259147-97259165 (+)	114,168 bp
Tssr132858	Chr15:97271251-97271265 (+)	126,270 bp
Tssr132859	Chr15:97271269-97271283 (+)	126,288 bp
Tssr132860	Chr15:97271290-97271303 (+)	126,309 bp
Tssr132861	Chr15:97271817-97271829 (+)	126,835 bp
Tssr132862	Chr15:97271860-97271869 (+)	126,877 bp
Tssr132863	Chr15:97271893-97271917 (+)	126,917 bp
Tssr132864	Chr15:97271927-97271940 (+)	126,946 bp
Tssr132865	Chr15:97272080-97272087 (+)	127,096 bp
Tssr132866	Chr15:97274569-97274583 (+)	129,588 bp
Tssr132867	Chr15:97275039-97275056 (+)	130,060 bp
Tssr132868	Chr15:97275061-97275077 (+)	130,081 bp
Tssr132869	Chr15:97281839-97281853 (+)	136,858 bp
Tssr132870	Chr15:97282477-97282514 (+)	137,508 bp
Tssr132871	Chr15:97283331-97283335 (+)	138,345 bp