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Megf8 Gene Detail
Summary
  • Symbol
    Megf8
  • Name
    multiple EGF-like-domains 8
  • Synonyms
    b2b1702Clo, b2b288Clo, Egfl4, m687Ddg, mKIAA0817
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446294
    NCBI Gene: 269878
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25016589-25065342 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446294
 protein coding gene Chr7:25016589-25065342 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031863
 protein coding gene Chr7:23772957-23831362 (+)
A/J MGP_AJ_G0031842
 protein coding gene Chr7:23163023-23213082 (+)
AKR/J MGP_AKRJ_G0031771
 protein coding gene Chr7:23706959-23760231 (+)
BALB/cJ MGP_BALBcJ_G0031849
 protein coding gene Chr7:23377048-23426762 (+)
C3H/HeJ MGP_C3HHeJ_G0031568
 protein coding gene Chr7:24141302-24193138 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032311
 protein coding gene Chr7:24568759-24631612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029366
 protein coding gene Chr7:24585450-24635731 (+)
CAST/EiJ MGP_CASTEiJ_G0030908
 protein coding gene Chr7:17614361-17677134 (+)
CBA/J MGP_CBAJ_G0031533
 protein coding gene Chr7:25483429-25542499 (+)
DBA/2J MGP_DBA2J_G0031687
 protein coding gene Chr7:23066408-23115183 (+)
FVB/NJ MGP_FVBNJ_G0031640
 protein coding gene Chr7:23066119-23118069 (+)
LP/J MGP_LPJ_G0031766
 protein coding gene Chr7:24077902-24130508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031677
 protein coding gene Chr7:25187258-25245129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032343
 protein coding gene Chr7:23414978-23466869 (+)
PWK/PhJ MGP_PWKPhJ_G0030632
 protein coding gene Chr7:18004319-18063248 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030463
 protein coding gene Chr7:14725722-14785503 (+)
WSB/EiJ MGP_WSBEiJ_G0031011
 protein coding gene Chr7:23590723-23649936 (+)



Homology
more
  • Human Ortholog
    MEGF8, multiple EGF like domains 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEGF8, multiple EGF like domains 8
  • Synonyms
    C19orf49, CRPT2, EGFL4, SBP1
  • Links
    NCBI Gene ID: 1954
    neXtProt AC: NX_Q7Z7M0
    UniProt: Q7Z7M0

  • Chr Location
    19q13.2; chr19:42325609-42378769 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Megf8 mouse models; 1 with human MEGF8 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 7 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    19 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    39
  • cDNA Data
    82
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269878 NCBI Gene Model | MGI Sequence Detail 48754 C57BL/6J ±  kb
    transcript NM_001160400 RefSeq | MGI Sequence Detail 10040 C57BL/6  
    polypeptide P60882 UniProt | EBI | MGI Sequence Detail 2789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 2
      cDNA 82
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142194, MGI:4455306, MGI:5311335, MGI:5437069
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory