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Ago2 Gene Detail
Summary
  • Symbol
    Ago2
  • Name
    argonaute RISC catalytic subunit 2
  • Synonyms
    1110029L17Rik, 2310051F07Rik, argonaute 2, Eif2c2, mKIAA1567
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446632
    NCBI Gene: 239528
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:72967693-73056777 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 33.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446632
 protein coding gene Chr15:72967693-73056784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021919
 protein coding gene Chr15:72801278-72893857 (-)
A/J MGP_AJ_G0021878
 protein coding gene Chr15:70203860-70295641 (-)
AKR/J MGP_AKRJ_G0021860
 protein coding gene Chr15:72001760-72091293 (-)
BALB/cJ MGP_BALBcJ_G0021885
 protein coding gene Chr15:70219619-70313098 (-)
C3H/HeJ MGP_C3HHeJ_G0021658
 protein coding gene Chr15:72149784-72244884 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022324
 protein coding gene Chr15:75594660-75686812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019861
 protein coding gene Chr15:66666453-66748678 (-)
CAST/EiJ MGP_CASTEiJ_G0021177
 protein coding gene Chr15:72894335-72988486 (-)
CBA/J MGP_CBAJ_G0021624
 protein coding gene Chr15:78050893-78146641 (-)
DBA/2J MGP_DBA2J_G0021749
 protein coding gene Chr15:69820901-69909257 (-)
FVB/NJ MGP_FVBNJ_G0021731
 protein coding gene Chr15:68815584-68910524 (-)
LP/J MGP_LPJ_G0021821
 protein coding gene Chr15:72831894-72924931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021754
 protein coding gene Chr15:83435456-83527835 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022346
 protein coding gene Chr15:72403250-72492132 (-)
PWK/PhJ MGP_PWKPhJ_G0020918
 protein coding gene Chr15:69907085-70002286 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020759
 protein coding gene Chr15:72281655-72371241 (-)
WSB/EiJ MGP_WSBEiJ_G0021229
 protein coding gene Chr15:72388464-72480977 (-)



Homology
more
  • Human Ortholog
    AGO2, argonaute RISC catalytic component 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGO2, argonaute RISC catalytic component 2
  • Synonyms
    CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10
  • Links
    NCBI Gene ID: 27161
    neXtProt AC: NX_Q9UKV8
    UniProt: Q9UKV8

  • Chr Location
    8q24.3; chr8:140520156-140642313 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human AGO2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with neural tube defects, abnormal forebrain patterning, enlarged hearts, pericardial swelling, delayed development, and defects in the yolk sac and placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    130
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    42
  • cDNA Data
    23
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239528 NCBI Gene Model | MGI Sequence Detail 89085 C57BL/6J ±  kb
    transcript NM_153178 RefSeq | MGI Sequence Detail 13793 C57BL/6  
    polypeptide Q8CJG0 UniProt | EBI | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 23
      Primer pair 6
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1915972, MGI:1917438, MGI:2145960, MGI:2146112, MGI:2146228
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 30
      Phenotypes 68
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:347998 Brindley E, et al., Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy. Front Mol Neurosci. 2023;16:1230942
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory