Kif26a MGI Mouse Gene Detail - MGI:2447072

Symbol

Kif26a
Name

kinesin family member 26A
Synonyms

mKIAA1236, N-11 kinesin

Feature Type

protein coding gene
IDs

MGI:2447072
NCBI Gene: 668303
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:112112642-112148181 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.14 cM
Mapping Data

1 experiment

SNPs within 2kb

940 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447072	protein coding gene	Chr12:112109378-112148181 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020149	protein coding gene	Chr12:114579673-114615176 (+)
A/J	MGP_AJ_G0020105	protein coding gene	Chr12:110167343-110203550 (+)
AKR/J	MGP_AKRJ_G0020080	protein coding gene	Chr12:113344257-113380547 (+)
BALB/cJ	MGP_BALBcJ_G0020090	protein coding gene	Chr12:110597037-110632555 (+)
C3H/HeJ	MGP_C3HHeJ_G0019892	protein coding gene	Chr12:113836666-113875156 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020535	protein coding gene	Chr12:118133675-118169240 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018148	protein coding gene	Chr12:106606505-106642870 (+)
CAST/EiJ	MGP_CASTEiJ_G0019433	protein coding gene	Chr12:108689443-108725716 (+)
CBA/J	MGP_CBAJ_G0019859	protein coding gene	Chr12:122648921-122687939 (+)
DBA/2J	MGP_DBA2J_G0019976	protein coding gene	Chr12:109652649-109688734 (+)
FVB/NJ	MGP_FVBNJ_G0019961	protein coding gene	Chr12:108457992-108495876 (+)
LP/J	MGP_LPJ_G0020051	protein coding gene	Chr12:114403480-114440565 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019999	protein coding gene	Chr12:125750501-125788062 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020564	protein coding gene	Chr12:112858878-112895220 (+)
PWK/PhJ	MGP_PWKPhJ_G0019194	protein coding gene	Chr12:104294676-104330778 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018997	protein coding gene	Chr12:107016658-107053151 (+)
WSB/EiJ	MGP_WSBEiJ_G0019492	protein coding gene	Chr12:113756230-113793921 (+)

Human Ortholog

KIF26A, kinesin family member 26A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF26A, kinesin family member 26A
Synonyms

CDCBM11
Links

HGNC:20226

NCBI Gene ID: 26153

neXtProt AC: NX_Q9ULI4

UniProt: Q9ULI4
Chr Location

14q32.33; chr14:104136454-104180894 (+) GRCh38

MGI Vertebrate Homology

Kif26a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF26A
Gene Tree

Kif26a

Diseases

1 with human KIF26A associations

				Human Disease	Mouse Models
				complex cortical dysplasia with other brain malformations IDs complex cortical dysplasia with other brain malformations DOID:0090131 OMIM:PS614039

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit premature death associated with megacolon and hyperganglionosis.

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

10
cDNA Data

11
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif26a

ZFIN kif26ab

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS49186.1

Ensembl

ENSMUSG00000021294 (Evidence)
NCBI Gene

668303

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021294	Ensembl Gene Model \| MGI Sequence Detail	35540	C57BL/6J	± kb
transcript	ENSMUST00000128402	Ensembl \| MGI Sequence Detail	6918	Not Applicable
polypeptide	ENSMUSP00000119482	Ensembl \| MGI Sequence Detail	1881	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009305 kinesin-like protein KIF26A

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 13

Genomic 1

cDNA 11

Primer pair 1

Microarray probesets 1

Summaries

All 28

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 6
Earliest

J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
Latest

J:330578 Qian X, et al., Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Dev Cell. 2022 Oct 24;57(20):2381-2396.e13

TSS for Kif26a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115369	Chr12:112112621-112112656 (+)	-3 bp
Tssr115370	Chr12:112112661-112112691 (+)	34 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24