Kif26b MGI Mouse Gene Detail - MGI:2447076

Symbol

Kif26b
Name

kinesin family member 26B
Synonyms

D230039L06Rik, N-11 kinesin

Feature Type

protein coding gene
IDs

MGI:2447076
NCBI Gene: 269152
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:178356690-178766765 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 83.16 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

11761 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447076	protein coding gene	Chr1:178356690-178766765 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016857	protein coding gene	Chr1:184838375-185268424 (+)
A/J	MGP_AJ_G0016835	protein coding gene	Chr1:177392030-177811418 (+)
AKR/J	MGP_AKRJ_G0016801	protein coding gene	Chr1:182680994-183099010 (+)
BALB/cJ	MGP_BALBcJ_G0016793	protein coding gene	Chr1:178023490-178436279 (+)
C3H/HeJ	MGP_C3HHeJ_G0016618	protein coding gene	Chr1:183414325-183841557 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017257	protein coding gene	Chr1:190847565-191283766 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014964	protein coding gene	Chr1:168401957-168804757 (+)
CAST/EiJ	MGP_CASTEiJ_G0016199	protein coding gene	Chr1:182718502-183150259 (+)
CBA/J	MGP_CBAJ_G0016592	protein coding gene	Chr1:197965097-198409160 (+)
DBA/2J	MGP_DBA2J_G0016698	protein coding gene	Chr1:176246809-176658588 (+)
FVB/NJ	MGP_FVBNJ_G0016694	protein coding gene	Chr1:174327021-174740165 (+)
LP/J	MGP_LPJ_G0016772	protein coding gene	Chr1:186114960-186544743 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016725	protein coding gene	Chr1:205145853-205579845 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017293	protein coding gene	Chr1:182403845-182831840 (+)
PWK/PhJ	MGP_PWKPhJ_G0015987	protein coding gene	Chr1:175311931-175730477 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015763	protein coding gene	Chr1:181349927-181791463 (+)
WSB/EiJ	MGP_WSBEiJ_G0016262	protein coding gene	Chr1:182623013-183057845 (+)

Human Ortholog

KIF26B, kinesin family member 26B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF26B, kinesin family member 26B
Links

HGNC:25484

NCBI Gene ID: 55083

neXtProt AC: NX_Q2KJY2

UniProt: Q2KJY2
Chr Location

1q44; chr1:245154985-245709432 (+) GRCh38

MGI Vertebrate Homology

Kif26b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF26B
Gene Tree

Kif26b

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Targeted

8
Genomic Mutations

2 involving Kif26b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

81 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

44
cDNA Data

12
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif26b

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All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS15559.1, CCDS48464.1

Ensembl

ENSMUSG00000026494 (Evidence)
NCBI Gene

269152

			Length	Strain/Species	Flank
genomic	269152	NCBI Gene Model \| MGI Sequence Detail	410076	C57BL/6J	± kb
transcript	NM_001161665	RefSeq \| MGI Sequence Detail	7422	ZRU/MplStud
polypeptide	Q7TNC6	UniProt \| EBI \| MGI Sequence Detail	2112	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009306 kinesin-like protein KIF26B

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q7TNC6 1 site, 1 N-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 2

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MGI:3045335, MGI:3607707

Summaries

All 44

Developmental Gene Expression 10

Gene Ontology 5

Phenotypes 13
Earliest

J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif26b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10402	Chr1:178356158-178356196 (+)	-513 bp
Tssr10403	Chr1:178356418-178356432 (+)	-265 bp
Tssr10404	Chr1:178356678-178356699 (+)	-1 bp
Tssr10405	Chr1:178383262-178383281 (+)	26,582 bp
Tssr10406	Chr1:178383435-178383446 (+)	26,751 bp
Tssr10407	Chr1:178383451-178383464 (+)	26,768 bp
Tssr10408	Chr1:178394042-178394046 (+)	37,354 bp
Tssr10410	Chr1:178567555-178567556 (+)	210,866 bp
Tssr10411	Chr1:178594558-178594564 (+)	237,871 bp
Tssr10412	Chr1:178625961-178625992 (+)	269,287 bp
Tssr10413	Chr1:178626013-178626032 (+)	269,333 bp
Tssr10414	Chr1:178648605-178648606 (+)	291,916 bp
Tssr10415	Chr1:178655671-178655675 (+)	298,983 bp
Tssr319	Chr1:178699007-178699008 (+)	342,318 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24