Cmtm3 MGI Mouse Gene Detail - MGI:2447162 - CKLF-like MARVEL transmembrane domain containing 3

Symbol

Cmtm3
Name

CKLF-like MARVEL transmembrane domain containing 3
Synonyms

9430096L06Rik, BNAS2, Cklfsf3

Feature Type

protein coding gene
IDs

MGI:2447162
NCBI Gene: 68119
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:105066042-105074304 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM
Mapping Data

2 experiments

SNPs within 2kb

303 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447162	protein coding gene	Chr8:105065993-105074304 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034008	protein coding gene	Chr8:106469449-106478072 (+)
A/J	MGP_AJ_G0033989	protein coding gene	Chr8:102246613-102253022 (+)
AKR/J	MGP_AKRJ_G0033915	protein coding gene	Chr8:105217199-105224277 (+)
BALB/cJ	MGP_BALBcJ_G0033982	protein coding gene	Chr8:102470149-102477216 (+)
C3H/HeJ	MGP_C3HHeJ_G0033694	protein coding gene	Chr8:105913689-105924359 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034502	protein coding gene	Chr8:110376207-110382683 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031445	protein coding gene	Chr8:95534138-95545074 (+)
CAST/EiJ	MGP_CASTEiJ_G0033021	protein coding gene	Chr8:105467127-105479309 (+)
CBA/J	MGP_CBAJ_G0033668	protein coding gene	Chr8:114030197-114038893 (+)
DBA/2J	MGP_DBA2J_G0033822	protein coding gene	Chr8:101613455-101620533 (+)
FVB/NJ	MGP_FVBNJ_G0033769	protein coding gene	Chr8:100544443-100552643 (+)
LP/J	MGP_LPJ_G0033913	protein coding gene	Chr8:106659629-106666110 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033811	protein coding gene	Chr8:117213849-117224290 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034520	protein coding gene	Chr8:105155933-105165847 (+)
PWK/PhJ	MGP_PWKPhJ_G0032723	protein coding gene	Chr8:101018422-101025493 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032562	protein coding gene	Chr8:103993836-104000756 (+)
WSB/EiJ	MGP_WSBEiJ_G0033136	protein coding gene	Chr8:105841042-105855214 (+)

Human Ortholog

CMTM3, CKLF like MARVEL transmembrane domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CMTM3, CKLF like MARVEL transmembrane domain containing 3
Synonyms

BNAS2, CKLFSF3
Links

HGNC:19174

NCBI Gene ID: 123920

neXtProt AC: NX_Q96MX0

UniProt: Q96MX0
Chr Location

16q22.1; chr16:66603874-66613892 (+) GRCh38

MGI Vertebrate Homology

Cmtm3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CMTM3
Gene Tree

Cmtm3

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

5
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele develop cardiac hypertrophy and exhibit exacerbated myocardial hypertrophy and cardiac dysfunction in response to angiotensin II infusion.

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

78
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cmtm3

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All Sequences

72
RefSeq

22
UniProt

5
CCDS

CCDS22577.1

Ensembl

ENSMUSG00000031875 (Evidence)
NCBI Gene

68119

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031875	Ensembl Gene Model \| MGI Sequence Detail	8263	C57BL/6J	± kb
transcript	ENSMUST00000212081	Ensembl \| MGI Sequence Detail	850	Not Applicable
polypeptide	ENSMUSP00000148682	Ensembl \| MGI Sequence Detail	184	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030700 CKLF-like MARVEL transmembrane domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR050578 MARVEL domain-containing and chemokine-like factor proteins

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All nucleic 79

cDNA 78

Primer pair 1

Microarray probesets 4

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MGI:1915369, MGI:2142526

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cmtm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79047	Chr8:105065979-105066028 (+)	-38 bp
Tssr79048	Chr8:105066924-105066973 (+)	907 bp
Tssr79049	Chr8:105066980-105067011 (+)	954 bp
Tssr79050	Chr8:105067017-105067035 (+)	984 bp
Tssr79051	Chr8:105067249-105067254 (+)	1,210 bp
Tssr79052	Chr8:105067279-105067290 (+)	1,243 bp
Tssr79053	Chr8:105067296-105067336 (+)	1,274 bp
Tssr79054	Chr8:105067341-105067355 (+)	1,306 bp
Tssr79055	Chr8:105067361-105067383 (+)	1,330 bp
Tssr79056	Chr8:105067392-105067403 (+)	1,356 bp
Tssr79057	Chr8:105067405-105067421 (+)	1,371 bp
Tssr79058	Chr8:105071905-105071925 (+)	5,873 bp
Tssr79059	Chr8:105073585-105073627 (+)	7,564 bp
Tssr79060	Chr8:105074091-105074104 (+)	8,056 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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