Mgrn1 MGI Mouse Gene Detail - MGI:2447670

Symbol

Mgrn1
Name

mahogunin, ring finger 1
Synonyms

2610042J20Rik, mKIAA0544, nc

Feature Type

protein coding gene
IDs

MGI:2447670
NCBI Gene: 17237
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:4704113-4756160 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.48 cM, cytoband A1
Mapping Data

24 experiments

SNPs within 2kb

1304 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447670	protein coding gene	Chr16:4703964-4756160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022475	protein coding gene	Chr16:1400472-1458154 (+)
A/J	MGP_AJ_G0022437	protein coding gene	Chr16:1214323-1268671 (+)
AKR/J	MGP_AKRJ_G0022414	protein coding gene	Chr16:1406692-1462834 (+)
BALB/cJ	MGP_BALBcJ_G0022442	protein coding gene	Chr16:1371900-1423403 (+)
C3H/HeJ	MGP_C3HHeJ_G0022209	protein coding gene	Chr16:1428373-1484169 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022891	protein coding gene	Chr16:1484447-1545044 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020412	protein coding gene	Chr16:1140570-1193034 (+)
CAST/EiJ	MGP_CASTEiJ_G0021735	protein coding gene	Chr16:1429875-1489247 (+)
CBA/J	MGP_CBAJ_G0022178	protein coding gene	Chr16:1565034-1620734 (+)
DBA/2J	MGP_DBA2J_G0022309	protein coding gene	Chr16:1321541-1373320 (+)
FVB/NJ	MGP_FVBNJ_G0022284	protein coding gene	Chr16:1314939-1368220 (+)
LP/J	MGP_LPJ_G0022377	protein coding gene	Chr16:1395701-1447777 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022306	protein coding gene	Chr16:1423350-1478817 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022903	protein coding gene	Chr16:1383970-1437582 (+)
PWK/PhJ	MGP_PWKPhJ_G0021475	protein coding gene	Chr16:1388867-1446952 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021306	protein coding gene	Chr16:1472420-1524455 (+)
WSB/EiJ	MGP_WSBEiJ_G0021784	protein coding gene	Chr16:1394121-1449368 (+)

Human Ortholog

MGRN1, mahogunin ring finger 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MGRN1, mahogunin ring finger 1
Synonyms

RNF156
Links

HGNC:20254

NCBI Gene ID: 23295

neXtProt AC: NX_O60291

UniProt: O60291
Chr Location

16p13.3; chr16:4616493-4690974 (+) GRCh38

MGI Vertebrate Homology

Mgrn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MGRN1
Gene Tree

Mgrn1

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Phenotype Summary

56 phenotypes from 8 alleles in 11 genetic backgrounds
1 images
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

37
Spontaneous

5
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for mutant alleles exhibit darkening of agouti hair and suppression of the obesity associated with certain agouti mutations. Homozygotes for an induced null mutation also have curly whiskers and develop a progressive spongiform neuropathology.

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All GO Annotations

43
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

59
cDNA Data

11
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgrn1

ZFIN mgrn1a

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All Sequences

126
RefSeq

19
UniProt

1
CCDS

CCDS49751.1, CCDS57016.1, CCDS88868.1, CCDS88869.1

Ensembl

ENSMUSG00000022517 (Evidence)
NCBI Gene

17237

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022517	Ensembl Gene Model \| MGI Sequence Detail	52048	C57BL/6J	± kb
transcript	ENSMUST00000023159	Ensembl \| MGI Sequence Detail	3095	Not Applicable
polypeptide	ENSMUSP00000023159	Ensembl \| MGI Sequence Detail	556	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030848 E3 ubiquitin-protein ligase MGRN1

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR045194 E3 ubiquitin-protein ligase MGRN1/RNF157-like

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q9D074 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 4

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MGD-MRK-12160, MGD-MRK-12784, MGI:1923814, MGI:2146731, MGI:96946

Summaries

All 92

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 36
Earliest

J:166121 LYON MF, et al., A test for mutagenicity of caffeine in mice. Z Vererbungsl. 1962;93:7-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mgrn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136882	Chr16:4703999-4704014 (+)	-106 bp
Tssr136883	Chr16:4704064-4704069 (+)	-46 bp
Tssr136884	Chr16:4704072-4704083 (+)	-35 bp
Tssr136885	Chr16:4704103-4704132 (+)	5 bp
Tssr136886	Chr16:4704135-4704148 (+)	29 bp
Tssr136887	Chr16:4704166-4704184 (+)	62 bp
Tssr136888	Chr16:4726573-4726576 (+)	22,462 bp
Tssr136889	Chr16:4731046-4731079 (+)	26,950 bp
Tssr136890	Chr16:4745595-4745620 (+)	41,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24