Fam83a MGI Mouse Gene Detail - MGI:2447773 - family with sequence similarity 83, member A

Symbol

Fam83a
Name

family with sequence similarity 83, member A
Synonyms

MGC:40696

Feature Type

protein coding gene
IDs

MGI:2447773
NCBI Gene: 239463
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:57848815-57874405 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.17 cM
Mapping Data

1 experiment

SNPs within 2kb

908 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447773	protein coding gene	Chr15:57847983-57874405 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021864	protein coding gene	Chr15:57137798-57164972 (+)
A/J	MGP_AJ_G0021824	protein coding gene	Chr15:54896993-54921892 (+)
AKR/J	MGP_AKRJ_G0021805	protein coding gene	Chr15:56399177-56427492 (+)
BALB/cJ	MGP_BALBcJ_G0021831	protein coding gene	Chr15:55124370-55149648 (+)
C3H/HeJ	MGP_C3HHeJ_G0021605	protein coding gene	Chr15:56543344-56571250 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022270	protein coding gene	Chr15:59366493-59392463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019807	protein coding gene	Chr15:51996157-52021376 (+)
CAST/EiJ	MGP_CASTEiJ_G0021122	protein coding gene	Chr15:57171438-57196459 (+)
CBA/J	MGP_CBAJ_G0021574	protein coding gene	Chr15:61434323-61460214 (+)
DBA/2J	MGP_DBA2J_G0021698	protein coding gene	Chr15:54822266-54846591 (+)
FVB/NJ	MGP_FVBNJ_G0021676	protein coding gene	Chr15:53872151-53897289 (+)
LP/J	MGP_LPJ_G0021768	protein coding gene	Chr15:56984241-57010288 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021700	protein coding gene	Chr15:66509226-66533598 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022293	protein coding gene	Chr15:56835747-56860843 (+)
PWK/PhJ	MGP_PWKPhJ_G0020867	protein coding gene	Chr15:54825154-54851106 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020704	protein coding gene	Chr15:56595056-56619822 (+)
WSB/EiJ	MGP_WSBEiJ_G0021177	protein coding gene	Chr15:56813105-56842444 (+)

Human Ortholog

FAM83A, family with sequence similarity 83 member A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM83A, family with sequence similarity 83 member A
Synonyms

BJ-TSA-9
Links

HGNC:28210

NCBI Gene ID: 84985

neXtProt AC: NX_Q86UY5

UniProt: Q86UY5
Chr Location

8q24.13; chr8:123178960-123210079 (+) GRCh38

MGI Vertebrate Homology

Fam83a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FAM83A
Gene Tree

Fam83a

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

3
Endonuclease-mediated

3
Radiation induced

1
Targeted

1
Genomic Mutations

4 involving Fam83a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

2
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam83a

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS27486.2

Ensembl

ENSMUSG00000051225 (Evidence)
NCBI Gene

239463

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051225	Ensembl Gene Model \| MGI Sequence Detail	25591	C57BL/6J	± kb
transcript	ENSMUST00000160942	Ensembl \| MGI Sequence Detail	2876	Not Applicable
polypeptide	ENSMUSP00000125464	Ensembl \| MGI Sequence Detail	436	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029484 protein FAM83A

(term hierarchy)
InterPro Domains

IPR012461 FAM83, N-terminal

IPR050944 Family with sequence similarity 83 (FAM83)

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 37

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam83a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131327	Chr15:57849269-57849290 (+)	465 bp
Tssr131328	Chr15:57865503-57865514 (+)	16,694 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24